CRETAN MEDITERRANEAN DIET FOR PREVENTION OF CORONARY HEART-DISEASE
CRETAN MEDITERRANEAN DIET FOR PREVENTION OF CORONARY HEART-DISEASE
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DOI：
10.1093/ajcn/61.6.1360s
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发表时间：
1995-06-01
影响因子：
7.1
通讯作者：
TOUBOL, P
中科院分区：
文献类型：
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作者：
RENAUD, S;DELORGERIL, M;TOUBOL, P
作为七个国家研究的结果，地中海饮食作为一种健康饮食得到了普及。然而，它并没有取代通常为冠心病患者开出的谨慎饮食。最近，我们在605名心肌梗塞恢复期患者中完成了一项二级、随机、前瞻性预防试验，在该试验中，我们比较了克里坦地中海饮食的适应情况和通常的处方饮食。在平均27个月的随访期后，在食用地中海饮食的组中，复发性心肌梗死、所有心血管事件、心脏病和总死亡率显著降低了70%。这些保护作用与血清总胆固醇、低密度脂蛋白胆固醇或高密度脂蛋白胆固醇浓度无关。相反，保护作用与观察到的血浆脂肪酸变化有关：n-3脂肪酸和油酸增加，亚油酸减少，这是由于亚麻酸和油酸的摄入量增加，但饱和脂肪酸和亚油酸的摄入量减少。此外，还观察到抗氧化剂维生素C和E的血浆浓度较高。我们的结论是，适合西方人群的克里特地中海饮食比谨慎饮食更有效地预防冠心病。因此，克里特人的良好预期寿命很大程度上可能要归功于他们的饮食。
As a result of the Seven Countries Study, the Mediterranean diet has been popularized as a healthy diet. Nevertheless, it has not replaced the prudent diet commonly prescribed to coronary patients. Recently, we completed a secondary, randomized, prospective prevention trial in 605 patients recovering from myocardial infarction in which we compared an adaptation of the Cretan Mediterranean diet with the usual prescribed diet. After a mean follow-up period of 27 mo, recurrent myocardial infarction, all cardiovascular events, and cardiac and total death were significantly decreased by > 70% in the group consuming the Mediterranean diet. These protective effects were not related to serum concentrations of total, low-density-lipoprotein (LDL), or high-density-lipoprotein (HDL) cholesterol. In contrast, protective effects were related to changes observed in plasma fatty acids: an increase in n-3 fatty acids and oleic acid and a decrease in linoleic acid that resulted from higher intakes of linolenic and oleic acids, but lower intakes of saturated fatty acids and Linoleic acid. In addition, higher plasma concentrations of antioxidant vitamins C and E were observed. We conclude that a Cretan Mediterranean diet adapted to a Western population protected against coronary heart disease much more efficiently than did the prudent diet. Thus, it appears that the favorable life expectancy of the Cretans could be largely due to their diet.