HISTOLOGIC AND ULTRASTRUCTURAL FEATURES OF NORMAL HUMAN PARIETAL PERICARDIUM
HISTOLOGIC AND ULTRASTRUCTURAL FEATURES OF NORMAL HUMAN PARIETAL PERICARDIUM
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DOI：
10.1016/0002-9149(80)90424-5
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发表时间：
1980-01-01
影响因子：
2.8
通讯作者：
ROBERTS, WC
中科院分区：
文献类型：
--
作者：
ISHIHARA, T;FERRANS, VJ;ROBERTS, WC
对七名患者的正常前壁心包的形态学研究表明，该组织由三层组成：（1）浆膜，由间皮细胞表面层和狭窄的间皮下间隙组成，（2）纤维层，含有不同方向的胶原原纤维和小弹性纤维层，（3）心外膜结缔组织层，主要含有大的粗胶原蛋白束，构成心包胸膜的一部分韧带。扫描电子显微镜检查对于研究心包间皮细胞的表面特征最有用，心包间皮细胞具有单个纤毛并被微绒毛覆盖。后者承受摩擦力并增加流体输送的表面积。相邻间皮细胞之间的连接复合物由桥粒和闭锁小带组成，桥粒增强细胞间粘附，闭锁小带形成通透性屏障。肌动蛋白样丝（直径 50 Å）存在于微绒毛和细胞紧邻的区域中；这些细丝介导细胞形状的变化。中间丝（直径 100 Å）与桥粒相连，并在核周区域形成束；这些细丝为细胞质提供结构支持。
Morphologic studies of normal anterior parietal pericardium from seven patients revealed this tissue to be composed of three layers: (1) the serosa, consisting of a surface layer of mesothelial cells and a narrow submesothellal space, (2) the fibrosa, containing variously oriented layers of collagen fibrils and small elastic fibers, and (3) the epipericardial connective tissue layer, containing mainly large coarse bundles of collagen and forming part of the pericardiosternal ligament. Scanning electron microscopic examination is most useful for study of the surface features of pericardial mesothelial cells, which have single cilia and are covered with microvilli. The latter bear friction and increase the surface area for fluid transport. Junctional complexes between adjacent mesothelial cells consist of desmosomes, which reinforce intercellular adhesion and zonulae occludentes, which form permeability barriers. Actin-like filaments (50 Å in diameter) are present in microvilli and in immediately subjacent regions of the cells; these filaments mediate changes in cell shape. Intermediate filaments (100 Å in diameter) are associated with desmosomes and form bundles in the perinuclear regions; these filaments provide structural support to the cytoplasm.