RU486 blocks the secondary surge of follicle-stimulating hormone in the rat without blocking the drop in serum inhibin.
RU486 blocks the secondary surge of follicle-stimulating hormone in the rat without blocking the drop in serum inhibin.
复制标题
RU486 可阻断大鼠卵泡刺激素的二次激增，但不会阻断血清抑制素的下降。
DOI：
10.1095/biolreprod46.2.220
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发表时间：
1992
影响因子：
3.6
通讯作者：
Schwartz,NB
中科院分区：
文献类型：
--
作者：
Knox,KL;Schwartz,NB
孕酮对血清黄体生成素和卵泡刺激素初级峰的释放有明显的刺激作用。关于黄体酮与继发性FSH激增之间的关系，我们知之甚少。我们用抗孕酮RU486阻断孕酮的作用，研究其对黄体生成素和卵泡刺激素一次峰的影响，特别是对二次峰的影响。用RU486处理发情前期大鼠1200h，于动情前期和动情期处死大鼠，测定血清促黄体生成素、卵泡刺激素和抑制素水平。在所有RU486治疗的大鼠中，尽管抑制素水平在一次峰后下降，但LH和FSH的一次峰显著减弱，二次FSH峰被完全消除。在RU486治疗后立即给予高替代剂量的黄体酮，并不能恢复黄体生成素和卵泡刺激素的一次峰，也不能恢复卵泡刺激素的二次峰。这些数据表明，除了抑制素下降外，其他因素也是导致第二次FSH激增的原因。
The stimulatory effect of progesterone on the release of the primary surges of serum LH and FSH is well characterized. Less is known about the relationship of progesterone to the secondary FSH surge. We used the antiprogesterone, RU486, to block the action of progesterone and studied the effects on the primary surges of LH and FSH, and especially on the secondary surge of FSH. Proestrous rats were treated with RU486 at 1 200 h. Rats were killed on proestrus and estrus, and serum levels of LH, FSH, and inhibin were measured. In all RU486-treated rats, the primary surges of LH and FSH were significantly attenuated, and the secondary FSH surge was completely abolished, despite a drop in inhibin levels following the primary surges. A high replacement dose of progesterone, delivered immediately after RU486 treatment, did not restore the primary surges of LH and FSH, or the secondary surge of FSH. These data suggest that other factors in addition to a drop in inhibin are responsible for producing the secondary FSH surge.