Efficient and selective deuteration of phenylalanine derivatives catalyzed by Pd/C
Efficient and selective deuteration of phenylalanine derivatives catalyzed by Pd/C
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DOI：
10.1055/s-2005-863730
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发表时间：
2005-03-21
期刊：
影响因子：
2
通讯作者：
Hirota, K
中科院分区：
文献类型：
--
作者：
Maegawa, T;Akashi, A;Hirota, K
本文报道了一种简便、有效的苯丙氨酸衍生物氘代反应方法，即Pd/C-H-2-D2 O体系。使用Pd/C作为催化剂，在苯丙氨酸衍生物的β-位发生选择性氘化，在110 ℃下具有高氘效率而没有外消旋化。此外，α-位在较高温度下被氘化。
A facile and efficient deuteration method of phenylalanine derivatives using a Pd/C-H-2-D2O system has been developed. Selective deuteration at the beta-position of phenylalanine derivatives occurred using Pd/C as a catalyst with high deuterium efficiency without racemization at 110 degrees C. Also, the alpha-position was deuterated at higher temperature.