Stem-cell-based strategies for the treatment of Parkinson's disease
Stem-cell-based strategies for the treatment of Parkinson's disease
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DOI：
10.1159/000101892
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发表时间：
2007-01-01
影响因子：
3
通讯作者：
Arenas, Ernest
中科院分区：
文献类型：
--
作者：
Parish, Clare L.;Arenas, Ernest
背景资料：细胞移植替代神经退行性疾病如帕金森病（PD）中丢失的神经元为许多患者提供了充满希望的前景。以前，胎儿移植物已被证明在PD患者中存活、整合并诱导功能恢复。然而，有限的组织可用性阻碍了这种疗法的广泛使用，并乞求对替代组织来源的需求。在这方面，干细胞可以构成这样的来源之一。目的/方法：在这篇综述中，我们概述了目前可用的各种类型的干细胞，并概述了它们可能用于PD的应用。我们不仅讨论了在细胞替代疗法中使用干细胞的明显可能性，而且还讨论了干细胞系在药物发现中的益处。结果/结论：携带与家族性PD相关的报告基因或基因突变的干细胞可能有助于识别新的药物靶点和随后开发PD新药。因此，干细胞是，并将在未来更加如此，在寻求新的治疗方法对神经退行性疾病，如PD的宝贵工具。版权所有（c）2007 S. Karger AG，巴塞尔。
Background: Cell transplantation to replace lost neurons in neurodegenerative diseases such as Parkinson's disease (PD) offers a hopeful prospect for many patients. Previously, fetal grafts have been shown to survive, integrate and induce functional recovery in PD patients. However, limited tissue availability has haltered the widespread use of this therapy and begs the demand for alternative tissue sources. In this regard, stem cells may constitute one such source. Objective/Methods: In this review we outline various types of stem cells currently available and provide an overview of their possible application for PD. We address not only the obvious possibility of using stem cells in cell replacement therapy but also the benefits of stem cell lines in drug discovery. Results/Conclusion: Stem cells carrying reporters or mutations in genes linked to familial PD are likely to contribute to the identification of new drug targets and subsequent development of new drugs for PD. Thus, stem cells are, and will be more so in the future, invaluable tools in the quest for new therapies against neurodegenerative diseases such as PD. Copyright (c) 2007 S. Karger AG, Basel.