Identification and characterization of an output neuron from the oscillatory molluscan olfactory network
Identification and characterization of an output neuron from the oscillatory molluscan olfactory network
复制标题
振荡软体动物嗅觉网络输出神经元的识别和表征
DOI：
10.1016/s0006-8993(01)03096-7
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发表时间：
2001
期刊：
影响因子：
2.9
通讯作者：
Y. Kirino
中科院分区：
文献类型：
--
作者：
S. Shimozono;Satoshi Watanabe;Tsuyoshi Inoue;Y. Kirino
嗅觉系统中的同步振荡被认为在嗅觉信息编码中发挥着关键作用。然而，它们在决定行为中的作用尚不清楚。作为理解相干振荡解码过程的第一步，我们在陆地蛞蝓边缘蜥蜴中寻找一个神经元，它接收来自前脑（PC）的输出信号，而前脑是蜥蜴的嗅觉中心。我们在元脑中发现了一个神经元，其神经突延伸至 PC 和元脑，并将其命名为元脑前脑神经元 (MPN)。 MPN 表现出与 PC 中局部场电位振荡同步的膜电位振荡。当我们切断PC时，MPN的膜电位振荡消失。在大脑的神经突上发现了许多静脉曲张，而在PC内部的神经突上没有发现静脉曲张。根据这些形态学和生理学结果，我们得出结论：MPN 是 PC 的输出神经元。 MPN 还接收来自上触手神经和下触手神经的单突触输入。因此，MPN 可以从两种途径接收嗅觉信息，一种直接来自感觉器官，另一种通过 PC，可能起到整合它们的作用。
Synchronous oscillations in olfactory systems have been thought to play critical roles in encoding olfactory information. However, their role in determining behavior is unknown. As a first step toward understanding the decoding process of coherent oscillation, we looked for a neuron in the terrestrial slug Limax marginatus that receives output signals from the procerebrum (PC), which is the olfactory center of Limax. We identified a neuron in the metacerebrum that extends its neurites into both the PC and the metacerebrum, and named it the metacerebro-procerebral neuron (MPN). The MPN exhibited a membrane potential oscillation that was synchronous with the local field potential oscillation in the PC. When we cut the PC off, the membrane potential oscillation of the MPN disappeared. Numerous varicosities were found on the neurites in the metacerebrum, while no varicosities were found on the neurites inside the PC. From these morphological and physiological results, we conclude that the MPN is an output neuron from the PC. The MPN also receives monosynaptic inputs from the superior and inferior tentacle nerves. The MPN thus may receive olfactory information from two pathways, one directly from the sensory organ and the other by way of the PC, possibly functioning to integrate them.