Endothelialization of titanium surfaces
Endothelialization of titanium surfaces
复制标题
DOI：
10.1002/adma.200700029
复制
发表时间：
2007-09-17
影响因子：
29.4
通讯作者：
Grinstaff, Mark W.
中科院分区：
文献类型：
--
作者：
Meyers, Steven R.;Hamilton, Paul T.;Grinstaff, Mark W.
合成了具有与Ti和内皮细胞结合的结构域的界面肽涂层（见图）。使用噬菌体展示鉴定与Ti具有特异性粘附的肽，并选择RGD基序用于细胞结合。该肽可以从水溶液中应用，并具有微摩尔结合亲和力。该涂层在静态和动态条件下均显著增强内皮细胞粘附和铺展。
An interfacial peptide coating possessing domains that bind to Ti and endothelial cells is synthesized (see figure). Peptides with specific adherence to Ti are identified using phage display, and the RGD motif was selected for cell binding. The peptide can be applied from aqueous solution and possesses micromolar binding affinities. The coating significantly enhances endothelial cell adhesion and spreading under both static and dynamic conditions.