Sense and specificity in neuronal calcium signalling.
Sense and specificity in neuronal calcium signalling.
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DOI：
10.1016/j.bbamcr.2014.10.029
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Haynes LP
中科院分区：
文献类型：
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作者：
Burgoyne RD;Haynes LP
神经元内游离钙浓度（[Ca 2 +]i）的变化在从微秒到数天的时间尺度上调节神经元功能的许多不同方面。神秘的是，一个单一的信号离子如何导致细胞功能的如此多样和具体的变化。这部分是由于Ca 2+信号本身的方面，包括其幅度，持续时间，定位和持续或振荡性质。Ca 2+信号的转导需要Ca 2+与各种Ca 2+传感器蛋白结合。这些传感器的不同特性对于差分信号处理是重要的，并且确定Ca 2+信号传导途径的生理特异性。特定Ca 2+传感器蛋白的特定作用的一个主要因素是它们与靶蛋白相互作用的性质以及这如何介导独特的调控模式。在这里，我们回顾了最近的进展，从结构分析和功能分析的模式生物，已经开始揭示的规则，Ca 2+传感器蛋白的特异性靶相互作用。我们讨论了三个案例研究例示不同方面的钙离子传感器/目标相互作用。本文是题为第13届欧洲钙研讨会特刊的一部分。Ca 2+在不同的时间尺度上调节神经元功能的多个方面。Ca 2+信号传导的特异性由Ca 2+传感器的性质决定。密切相关的Ca 2+传感器的不同性质有助于特异性。Ca 2+传感器的结构决定了靶蛋白相互作用的特异性。我们讨论了三个案例研究涉及钙调素，NCS蛋白和CaBP蛋白。这些例子说明了Ca 2+传感器的结构-功能关系。
Changes in the intracellular free calcium concentration ([Ca2 +]i) in neurons regulate many and varied aspects of neuronal function over time scales from microseconds to days. The mystery is how a single signalling ion can lead to such diverse and specific changes in cell function. This is partly due to aspects of the Ca2 + signal itself, including its magnitude, duration, localisation and persistent or oscillatory nature. The transduction of the Ca2 + signal requires Ca2 + binding to various Ca2 + sensor proteins. The different properties of these sensors are important for differential signal processing and determine the physiological specificity of Ca2 + signalling pathways. A major factor underlying the specific roles of particular Ca2 + sensor proteins is the nature of their interaction with target proteins and how this mediates unique patterns of regulation. We review here recent progress from structural analyses and from functional analyses in model organisms that have begun to reveal the rules that underlie Ca2 + sensor protein specificity for target interaction. We discuss three case studies exemplifying different aspects of Ca2 + sensor/target interaction. This article is part of a special issue titled the 13th European Symposium on Calcium. Ca2 + regulates multiple aspects of neuronal function over varying time scales. The specificity of Ca2 + signalling is determined by the properties of Ca2 + sensors Differing properties of closely related Ca2 + sensors contributes to specificity. The structure of Ca2 + sensors determines specificity of target protein interactions. We discuss three case studies involving calmodulin, NCS proteins and CaBP proteins. The examples illustrate the structural–function relationships of Ca2 + sensors.