Individual Differences in Pain Sensitivity Vary as a Function of Precuneus Reactivity
Individual Differences in Pain Sensitivity Vary as a Function of Precuneus Reactivity
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DOI：
10.1007/s10548-013-0291-0
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发表时间：
2014-05-01
期刊：
影响因子：
2.7
通讯作者：
Whittingstall, Kevin
中科院分区：
文献类型：
--
作者：
Goffaux, Philippe;Girard-Tremblay, Lydia;Whittingstall, Kevin
尽管人类对疼痛刺激的敏感程度存在很大差异，但这种差异背后的神经相关性仍然知之甚少。鉴于基线疼痛敏感性评分与发生难治性慢性疼痛的风险密切相关，更好地理解这一点非常重要。为了解决这个问题，我们使用了匹配的感知范式，它使我们能够控制主观体验的个体差异。通过测量主观疼痛、伤害性屈曲反射和体感诱发脑电位（通过源定位分析），我们能够绘制大脑对疼痛的顺序反应，同时还研究其与疼痛敏感性（即体验疼痛所需的刺激强度的变化）和脊髓活动的关系。我们发现健康成年人的疼痛敏感性与对侧楔前叶的疼痛诱发反应密切相关。重要的是，楔前叶对大脑中疼痛的实际表征没有贡献，这表明疼痛敏感性和疼痛表征取决于不同的神经元子系统。
Although humans differ widely in how sensitive they are to painful stimuli, the neural correlates underlying such variability remains poorly understood. A better understanding of this is important given that baseline pain sensitivity scores relate closely to the risk of developing refractory, chronic pain. To address this, we used a matched perception paradigm which allowed us to control for individual variations in subjective experience. By measuring subjective pain, nociceptive flexion reflexes, and, somatosensory evoked brain potentials (with source localization analysis), we were able to map the brain's sequential response to pain while also investigating its relationship to pain sensitivity (i.e. change in the stimulation strength necessary to experience pain) and spinal cord activity. We found that pain sensitivity in healthy adults was closely tied to pain-evoked responses in the contralateral precuneus. Importantly, the precuneus did not contribute to the actual representation of pain in the brain, suggesting that pain sensitivity and pain representation depend on separate neuronal sub-systems.