Use of Mouse Models in Atherosclerosis Research
Use of Mouse Models in Atherosclerosis Research
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DOI：
10.1007/978-1-4939-2929-0_1
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Reardon, Catherine A.
中科院分区：
文献类型：
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作者：
Getz, Godfrey S.;Reardon, Catherine A.
心血管疾病是大多数发达国家的主要死亡原因，并且这种疾病的社会和经济负担相当高。动脉粥样硬化是大多数心血管疾病（包括心肌梗死和中风）的主要基础。转基因小鼠模型，特别是载脂蛋白E或LDL受体缺陷的小鼠，已被广泛用于临床前动脉粥样硬化研究，以深入了解这种病理学的机制。本章回顾了几种小鼠动脉粥样硬化模型的进展和消退，以及免疫细胞在疾病进展和小鼠动脉粥样硬化发生的遗传学中的作用。
Cardiovascular disease is the major cause of death in most developed nations and the social and economic burden of this disease is quite high. Atherosclerosis is a major underlying basis for most cardiovascular diseases including myocardial infarction and stroke. Genetically modified mouse models, particularly mice deficient in apoprotein E or the LDL receptor, have been widely used in preclinical atherosclerosis studies to gain insight into the mechanisms underlying this pathology. This chapter reviews several mouse models of atherosclerosis progression and regression as well as the role of immune cells in disease progression and the genetics of murine atherogenesis.