Anger attacks in major depressive disorder and serum levels of homocysteine
Anger attacks in major depressive disorder and serum levels of homocysteine
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DOI：
10.1016/j.biopsych.2005.08.026
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发表时间：
2006-08-01
影响因子：
10.6
通讯作者：
Fava, Maurizio
中科院分区：
文献类型：
--
作者：
Fraguas, Renerio, Jr.;Papakostas, George I.;Fava, Maurizio
背景：同型半胱氨酸水平的升高分别与愤怒和抑郁有关。我们调查了重型抑郁症（MDD）的愤怒发作与血清同型半胱氨酸（homocystein.Methods）水平的关系：在192例非精神病性MDD门诊患者中测定了血清同型半胱氨酸水平，平均年龄39.9 ± 10.7（范围19-65），53%的女性，在基线的开放试验抗抑郁药治疗。我们使用马萨诸塞州综合医院愤怒发作问卷来评估愤怒发作，使用DSM-IITR轴I障碍结构化临床访谈-患者版（SCID-I/P）诊断MDD和17项汉密尔顿抑郁量表测量抑郁的严重程度。在多元回归分析中，根据抑郁、肌酐、维生素B-12、叶酸、年龄、吸烟等参数调整愤怒发作，饮酒量、血清同型半胱氨酸水平与抑郁发作时间呈正相关（t值，3.01; 95%置信区间[CI]，0.09至0.43; p = 0.004）和HAM-D-17评分（t值，2.48; 95%CI，0.07至0.64; p = 0.016），但在那些没有愤怒attacks.Conclusions：愤怒攻击MDD可能缓和同型半胱氨酸血清水平的关系与抑郁发作的严重程度和长度。未来的研究是必要的，以确认和澄清这种调节作用的性质。
Background: increased levels of homocysteine have been associated with anger and depression separately. We investigated the association of anger attacks in major depressive disorder (MDD) with serum levels of homocysteine.Methods: Homocysteine serum levels were measured in 192 outpatients with nonpsycbotic MDD, mean age 39.9 +/- 10.7 (range 19-65), 53% women, at baseline of an open-trial antidepressant treatment. We used the Massachusetts General Hospital Anger Attacks Questionnaire to evaluate anger attacks, the Structured Clinical Interview for DSM-IITR Axis I Disorders-Patient Edition (SCID-I/P) to diagnose MDD and the 17-item Hamilton Rating Scale for Depression to measure depression severity.Results: In the multiple regression analysis split by anger attacks adjusted for parameters of depression, creatinine, vitamin B-12, folate, age, smoking, and alcohol consumption, serum levels of homocysteine were positively correlated with length of current major depressive episode (t value, 3.01; 95% confidence interval [CI], .09 to .43; p =.004) and HAM-D-17 scores (t value, 2.48; 95% CI, .07 to 0.64; p =.016) in patients with anger attacks but not in those without anger attacks.Conclusions: Anger attacks in MDD may moderate the relationship of homocysteine serum levels with the severity and length of the depressive episode. Future studies are warranted to confirm and clarify the nature of this moderating effect.