EFFICACY OF ANTIHYPERTENSIVE DRUG TREATMENT ACCORDING TO AGE, SEX, BLOOD PRESSURE, AND PREVIOUS CARDIOVASCULAR DISEASE IN PATIENTS OVER THE AGE OF 60
EFFICACY OF ANTIHYPERTENSIVE DRUG TREATMENT ACCORDING TO AGE, SEX, BLOOD PRESSURE, AND PREVIOUS CARDIOVASCULAR DISEASE IN PATIENTS OVER THE AGE OF 60
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根据年龄、性别、血压和既往心血管疾病对 60 岁以上患者进行抗高血压药物治疗的疗效
DOI：
10.1016/s0140-6736(86)92424-4
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
B. Williams
中科院分区：
文献类型：
--
作者：
A. Amery;R. Brixko;D. Clement;A. Schaepdryver;R. Fagard;J. Forte;Henry Jf;G. Leonetti;K. O'malley;T. Strasser;W. Birkenhäger;C. Bulpitt;M. Deruyttere;C. Dollery;F. Forette;R. Hamdy;J. Joossens;P. Lund;Petrie Jc;J. Tuomilehto;B. Williams
欧洲老年人高血压工作组 (EWPHE) 试验的结果对年龄、性别、血压和既往心血管疾病的关系进行了分析。心血管死亡率和心血管研究终止事件与治疗、年龄、随机分组时的心血管并发症以及收缩压（而非舒张压）显着且独立相关。试验中观察到的治疗益处似乎与入组血压以及入组时是否存在心血管并发症无关。有一些证据表明治疗效果随着年龄的增长而降低。对于 80 岁以上的患者（其中绝大多数是女性），治疗几乎没有或根本没有益处。
Results of the European Working Party on High Blood Pressure in the Elderly (EWPHE) trial have been analysed in relation to age, sex, blood pressure, and previous cardiovascular disease. Cardiovascular mortality and the cardiovascular study-terminating events were significantly and independently related to treatment, age, cardiovascular complications at randomisation, and systolic but not diastolic blood pressure. The benefits of treatment observed in the trial seemed to be independent of entry blood pressure and the presence or absence of cardiovascular complications at entry. There was some evidence that treatment effect decreases with advancing age. Little or no benefit from treatment could be demonstrated in patients over the age of 80 years, the great majority of whom were women.