Postsynaptic depolarization requirements for LTP and LTD: a critique of spike timing-dependent plasticity
Postsynaptic depolarization requirements for LTP and LTD: a critique of spike timing-dependent plasticity
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DOI：
10.1038/nn0705-839
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发表时间：
2005-07-01
影响因子：
25
通讯作者：
Spruston, N
中科院分区：
文献类型：
--
作者：
Lisman, J;Spruston, N
长时程增强和长时程抑制需要突触后去极化，目前许多模型将其归因于反向传播动作电位。然而，新的实验工作表明，其他机制可以导致树突去极化，反向传播动作电位可能既不必要也不足以在体内突触可塑性。
Long-term potentiation and long-term depression require postsynaptic depolarization, which many current models attribute to backpropagating action potentials. New experimental work suggests, however, that other mechanisms can lead to dendritic depolarization, and that backpropagating action potentials may be neither necessary nor sufficient for synaptic plasticity in vivo.