Choosing Relatives for DNA Identification of Missing Persons
Choosing Relatives for DNA Identification of Missing Persons
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DOI：
10.1111/j.1556-4029.2010.01631.x
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发表时间：
2011-01-01
影响因子：
1.6
通讯作者：
Chakraborty, Ranajit
中科院分区：
文献类型：
--
作者：
Ge, Jianye;Budowle, Bruce;Chakraborty, Ranajit
基于DNA的分析是失踪人员身份识别案件不可或缺的一部分。在没有直接亲属关系的情况下，可利用间接亲属关系通过亲属关系分析查明失踪人员。一般来说，更多的参考亲属可以提高识别的准确性。但是，键入多个引用的成本很高。因此，有时，可能需要决定哪些亲属类型。在这项研究中，系谱37个常见的参考方案与13个CODIS STR进行了模拟排名的信息内容的不同组合的亲属。结果证实，一阶亲属（父母和全同胞）是最首选的亲属，以确定失踪人员;全同胞也是信息。参考之间较少的遗传依赖性提供较高的平均似然比。远亲可能不会有帮助，仅通过常染色体标记。但是基于谱系的Y染色体和线粒体DNA标记可以增加似然比或作为过滤器来排除推定的关系。
DNA-based analysis is integral to missing person identification cases. When direct references are not available, indirect relative references can be used to identify missing persons by kinship analysis. Generally, more reference relatives render greater accuracy of identification. However, it is costly to type multiple references. Thus, at times, decisions may need to be made on which relatives to type. In this study, pedigrees for 37 common reference scenarios with 13 CODIS STRs were simulated to rank the information content of different combinations of relatives. The results confirm that first-order relatives (parents and fullsibs) are the most preferred relatives to identify missing persons; fullsibs are also informative. Less genetic dependence between references provides a higher on average likelihood ratio. Distant relatives may not be helpful solely by autosomal markers. But lineage-based Y chromosome and mitochondrial DNA markers can increase the likelihood ratio or serve as filters to exclude putative relationships.