Actin Cytoskeleton Reorganization Correlates with Cofilin Nuclear Expression and Ultrastructural Changes in CHO AA8 Cell Line after Apoptosis and Mitotic Catastrophe Induction by Doxorubicin
Actin Cytoskeleton Reorganization Correlates with Cofilin Nuclear Expression and Ultrastructural Changes in CHO AA8 Cell Line after Apoptosis and Mitotic Catastrophe Induction by Doxorubicin
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DOI：
10.3109/01913123.2010.548113
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发表时间：
2011-05-01
影响因子：
1
通讯作者：
Grzanka, Alina
中科院分区：
文献类型：
--
作者：
Grzanka, Dariusz;Marszalek, Andrzej;Grzanka, Alina
用荧光显微镜和电子显微镜观察阿霉素对CHO aa8细胞cofilin和肌动蛋白表达的影响。经阿霉素处理后，以不同方式观察到细胞胞核中有粘连蛋白和肌动蛋白的存在。经历有丝分裂灾难的细胞表现出一些完全具有特征的特征，以及其他类型细胞死亡的重叠元素。此外，作者认为，正如这里定义的那样，F-肌动蛋白的重组可能参与了所有细胞死亡过程。Cofilin核表达的变化与F-肌动蛋白胞浆-核转位及其核内动态重组有关。
The effect of doxorubicin on the expression of cofilin and actin in CHO AA8 cells was estimated by fluorescence and electron microscopy. The presence of cofilin and actin was observed particularly in the nuclei of cells by different modes after treatment by doxorubicin. Cells undergoing mitotic catastrophe expressed some entirely characteristic features together with overlapping elements of other types of cell death. Additionally, the authors suggest that, as defined here, reorganization of F-actin might be involved in all cell death processes. Changes in the nuclear expression of cofilin are related to F-actin cytoplasm-nuclear translocation and its intranuclear dynamic reorganization.