Further evidence against the implication of active cytomegalovirus infection in vascular atherosclerotic diseases
Further evidence against the implication of active cytomegalovirus infection in vascular atherosclerotic diseases
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DOI：
10.1016/s0021-9150(00)00744-9
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发表时间：
2001-08-01
期刊：
影响因子：
5.3
通讯作者：
Capobianchi, MR
中科院分区：
文献类型：
--
作者：
Borgia, MC;Mandolini, C;Capobianchi, MR
巨细胞病毒（CMV）对动脉粥样硬化病变形成和进展的可能作用仍有争议。我们通过对61例不稳定型心绞痛患者的分析，评估了活动性持续CMV感染与不稳定型动脉粥样硬化病变进展相关的可能性。急性心肌梗死（n = 43）、稳定型心绞痛（n = 26）和外周动脉病（n = 22）与健康受试者（n = 30）相比。我们特别评估了：通过评估抗CMV IgG抗体，既往暴露于CMV;通过评估血清中的抗CMV IgM抗体和循环白细胞介素（IL）-8，持续CMV感染;外周血单核细胞（PBMC）中的CMV DNA血症。与健康受试者相比，所有组患者的平均IgG值均显著增加。CMV特异性IgM和CMV DNA血症在对照组和患者中均检测不到。循环IL-8在经历活动性CMV感染的一组个体中显著升高，与对照受试者相比，在心血管疾病患者中并不显著升高。这些发现证实了先前的证据，即动脉粥样硬化病变患者CMV感染的暴露增加。然而，他们提供了进一步的证据，反对活动性系统性CMV感染在心血管疾病，特别是涉及斑块不稳定性的发病机制中的直接影响。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
The possible contribution of cytomegalovirus (CMV) to pathogenetic events associated with atherosclerotic lesion establishment and progression is still controversial. We evaluated the possibility that active ongoing CMV infection could be correlated to evolution of unstable atheromatous lesion, by analyzing patients suffering from unstable angina (n = 61). acute myocardial infarction (n = 43), stable angina (n = 26) and peripheral arteriopathy (n = 22) as compared to healthy subjects (n = 30). Particularly, we assessed: past exposure to CMV by evaluating anti-CMV IgG antibodies; ongoing CMV infection by evaluating anti-CMV IgM antibodies and circulating interleukin (IL)-8 in serum; and CMV DNAemia in peripheral blood mononuclear cells (PBMC). Mean IgG values were significantly increased in patients from all groups, as compared to healthy subjects. CMV-specific IgM, as well as CMV DNAemia, were undetectable in both controls and patients. Circulating IL-8, significantly elevated in a group of individuals experiencing active CMV infection, was not significantly higher in cardiovascular disease patients, as compared to control subjects. These findings confirm previous evidence from the increased exposure to CMV infection in patients with atheromatous lesions. However, they provide further evidence against a direct implication of active systemic CMV infection in the pathogenesis of cardiovascular diseases, particularly those involving plaque instability. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.