Role for nanomaterial-autophagy interaction in neurodegenerative disease
Role for nanomaterial-autophagy interaction in neurodegenerative disease
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DOI：
10.4161/auto.7142
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发表时间：
2008-11-16
期刊：
影响因子：
13.3
通讯作者：
Johnson, Denise N.
中科院分区：
文献类型：
--
作者：
Stern, Stephan T.;Johnson, Denise N.
纳米技术是对尺寸在1-100纳米范围内的材料的控制和操纵。由于对纳米技术潜在有益应用的研究不断增加，迫切需要研究可能的健康风险。一些研究人员，包括我们实验室的研究人员，已经证明了当细胞接触某些纳米材料时，自噬空泡的水平增加，包括碳和金属纳米颗粒。虽然这种自噬活性的明显增加可能是细胞对纳米材料清除的适当反应，但纳米材料与自噬途径之间的相互作用往往是破坏性的，导致严重的形态变化和细胞死亡。有趣的是，流行病学研究已经确定了暴露在燃烧产生的环境颗粒物(主要是纳米级)和神经条件与阿尔茨海默氏症和帕金森氏病样病理之间的联系。由于自噬受损可能在这些疾病和其他疾病的发病机制中发挥重要作用，因此推测纳米颗粒可能参与了这一过程是有趣的。纳米材料与自噬途径的相互作用，以及由此导致的自噬功能障碍的潜在负面后果，应该进一步探讨。
Nanotechnology is the control and manipulation of materials in the size range of 1-100 nm. Due to increasing research into the potential beneficial applications of nano technology, there is an urgent need for the study of possible health risks. Several researchers, including those in our laboratory, have demonstrated elevated levels of autophagic vacuoles upon exposure of cells to certain nanomaterials, including carbon- and metal-based nanoparticles. While this apparent increase in autophagic activity may be an appropriate cellular response toward nanomaterial clearance, often the interaction between nanomaterials and the autophagy pathway is disruptive, resulting in severe morphological changes and coincident cell death. Interestingly, epidemiological studies have identified an association between exposure to combustion -derived ambient particles (which are predominantly nanoscale) and neurological conditions with Alzheimer's and Parkinson's disease-like pathologies. Becuse impaired autophagy may play an important role in the pathogenesis of these and other diseases, it is intriguing to speculate about the plausible involvement of nanoscale particulates in this process. The interaction of nanomaterials with the autophagy pathway, and the potential negative consequences of resulting autophagy dysfunction, should be explored further.