Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of oncogenic KRAS
Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of oncogenic KRAS
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DOI：
10.1002/pbc.26496
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发表时间：
2017-09-01
影响因子：
3.2
通讯作者：
Kiyokawa, Nobutaka
中科院分区：
文献类型：
--
作者：
Osumi, Tomoo;Kato, Motohiro;Kiyokawa, Nobutaka
以往的研究报道了几例青少年粒单核细胞白血病（JMML）发展急变在惰性的临床过程中，但转化的潜在机制仍然没有很好地理解。在这份报告中，我们描述了一个JMML的情况下，可能造成额外的拷贝数增益的KRAS突变等位基因的急变转化。我们已经发现，突变等位基因的拷贝数增加是JMML中胚细胞转化的另一个可能原因。
Previous studies have reported several cases of juvenile myelomonocytic leukemia (JMML) developing blastic transformation during an indolent clinical course, but the underlying mechanism of transformation is still not well understood. In this report, we describe a case of JMML with blastic transformation possibly caused by additional copy number gains of the KRAS mutant allele. We have discovered that the copy number gain of the mutant allele is an additional possible cause of blastic transformation in JMML.