Low-intensity light therapy: Exploring the role of redox mechanisms
Low-intensity light therapy: Exploring the role of redox mechanisms
复制标题
DOI：
10.1089/pho.2007.2184
复制
发表时间：
2008-08-01
影响因子：
--
通讯作者：
Mills, Paul J.
中科院分区：
文献类型：
--
作者：
Tafur, Joseph;Mills, Paul J.
低强度光疗法（LILT）似乎是通过新认识的光受体系统。线粒体电子传递链已被证明对红光和近红外（NIR）光具有光敏性。虽然其潜在机制尚未明确阐明，但线粒体光刺激已显示出增加ATP产生并引起活性氧（ROS）的瞬时增加。在某些细胞中，这个过程似乎参与了还原/氧化（氧化还原）信号。已知氧化还原机制涉及细胞内稳态和增殖控制。在植物中，光刺激类似的光合电子传递链导致氧化还原信号，已知是细胞功能不可或缺的。在基因治疗研究中，紫外线激光被用来通过一个似乎也涉及氧化还原信号的过程来光刺激细胞。可见光和近可见光的低强度光似乎可以用来调节一些非光合作用细胞的细胞生理学，通过现有的细胞生理学的氧化还原机制起作用。以这种方式，LILT可以起到促进增殖和/或细胞稳态的作用。了解氧化还原状态和信号传导在LILT中的作用可能有助于指导未来的治疗，特别是在与促氧化条件相关的条件下。
Low-intensity light therapy (LILT) appears to be working through newly recognized photoacceptor systems. The mitochondrial electron transport chain has been shown to be photosensitive to red and near-infrared (NIR) light. Although the underlying mechanisms have not yet been clearly elucidated, mitochondrial photostimulation has been shown to increase ATP production and cause transient increases in reactive oxygen species (ROS). In some cells, this process appears to participate in reduction/oxidation (redox) signaling. Redox mechanisms are known to be involved in cellular homeostasis and proliferative control. In plants, photostimulation of the analogous photosynthetic electron transport chain leads to redox signaling known to be integral to cellular function. In gene therapy research, ultraviolet lasers are being used to photostimulate cells through a process that also appears to involve redox signaling. It seems that visible and near visible low-intensity light can be used to modulate cellular physiology in some nonphotosynthetic cells, acting through existing redox mechanisms of cellular physiology. In this manner, LILT may act to promote proliferation and/or cellular homeostasis. Understanding the role of redox state and signaling in LILT may be useful in guiding future therapies, particularly in conditions associated with pro-oxidant conditions.