Circulating osteocalcin levels were not significantly associated with the risk of incident type 2 diabetes mellitus in elderly Japanese men: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study
Circulating osteocalcin levels were not significantly associated with the risk of incident type 2 diabetes mellitus in elderly Japanese men: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study
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DOI：
10.1016/j.bone.2021.115912
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发表时间：
2021-03-16
期刊：
影响因子：
4.1
通讯作者：
Kurumatani, Norio
中科院分区：
文献类型：
--
作者：
Iki, Masayuki;Yura, Akiko;Kurumatani, Norio
简介：横断面研究表明，2 型糖尿病 (T2DM) 患者的骨钙素 (OC) 和羧化不足 OC (ucOC) 循环水平较低。这项纵向研究旨在探讨基线时低 OC 或 ucOC 水平是否与 T2DM 发生风险相关。方法：我们对 1700 名社区居住的日本男性（> 65 岁）进行了检查，排除了有疾病史（T2DM 除外）或服用影响骨骼和葡萄糖代谢的药物的人。 T2DM 定义为空腹血糖 (FPG) >126 mg/dl 或糖化血红蛋白 A1c (HbA1c) >6.5%。基线时没有流行 T2DM 的参与者被邀请参加基线后 5 年和 10 年的后续调查。结果：在参与者中，309 名患有 T2DM 的参与者在基线时的血清 OC 和 ucOC 水平显着低于未患有 T2DM 的参与者。排除这些参与者后，在第一次和第二次随访调查中分别确定了 46 名和 57 名患有 T2DM 的参与者。与没有发生 T2DM 的参与者相比，这些参与者在基线时的 OC 和 ucOC 水平没有表现出显着差异，尽管他们基线时的 FPG 和 HbA1c 水平显着高于没有发生 T2DM 的参与者。血糖指数升高先于 OC 和 ucOC 水平降低。基线时的 OC 和 ucOC 水平与后续调查中发现的 T2DM 事件风险没有显着相关性。结论：基线时的 OC 和 ucOC 水平与 T2DM 发生风险没有显着相关性。我们的结果不支持动物研究的结果，即 ucOC 是调节葡萄糖代谢的激素。
Introduction: Cross-sectional studies have shown that patients with type 2 diabetes mellitus (T2DM) have low circulating levels of osteocalcin (OC) and undercarboxylated OC (ucOC). This longitudinal study aimed to examine whether low OC or ucOC levels at baseline are associated with the risk of incident T2DM. Methods: We examined 1700 community-dwelling Japanese men (>65 years) after excluding those with history of diseases (other than T2DM) or medications that affect bone and glucose metabolism. T2DM was defined as fasting plasma glucose (FPG) >126 mg/dl or glycated hemoglobin A1c (HbA1c) >6.5%. Participants without prevalent T2DM at baseline were invited to follow-up surveys 5 and 10 years after baseline. Results: Among the participants, 309 with prevalent T2DM showed significantly lower serum OC and ucOC levels at baseline than those without. After excluding these participants, 46 and 57 participants with incident T2DM were identified in the first and second follow-up surveys, respectively. These participants did not show significantly different OC and ucOC levels at baseline relative to those without T2DM, although their FPG and HbA1c levels at baseline were significantly higher compared to those without incident T2DM. Increase in glycemic indices preceded decrease in OC and ucOC levels. OC and ucOC levels at baseline were not significantly associated with the risk of incident T2DM identified in the follow-up surveys. Conclusions: OC and ucOC levels at baseline were not significantly associated with the risk of incident T2DM. Our results do not support the findings of animal studies that ucOC is a hormone regulating glucose metabolism.