Intermittent foot shock stress prolongs the telogen stage in the hair cycle of mice
Intermittent foot shock stress prolongs the telogen stage in the hair cycle of mice
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DOI：
10.1034/j.1600-0625.2002.120403.x
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发表时间：
2003-08-01
影响因子：
3.6
通讯作者：
Kawana, S
中科院分区：
文献类型：
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作者：
Aoki, E;Shibasaki, T;Kawana, S
压力显著影响皮肤疾病和皮肤功能。最近，压力和皮肤状况之间的相互作用已经在动物模型中使用各种全身性压力源进行了研究。本文研究了间歇性足电击应激对C57 BL/6小鼠毛周期的影响。经过2周的间歇性足部电击应激，我们检查了脱毛同步毛发周期的变化宏观和组织学，我们还测量了血浆皮质酮水平。我们发现，足部电击应激延长了毛发生长的休止期，并延迟了随后的毛发生长期诱导。促肾上腺皮质激素释放因子或促肾上腺皮质激素释放因子受体阳性细胞在应激或对照小鼠皮肤中的分布模式与有序毛发周期中的分布模式相同。值得注意的是，本研究中在应激小鼠的休止期卵泡中观察到促肾上腺皮质激素释放因子阳性角质形成细胞，而在非应激小鼠的休止期卵泡中为阴性。应激组血浆皮质酮水平显著高于对照组。这些结果表明，血浆皮质酮水平的增加可能参与应激诱导的毛发周期延迟的机制。
Stress significantly influences skin diseases and cutaneous functions. Recently, interactions between stress and skin conditions have been studied in animal models using various systemic stressors. Here, we studied the effect of intermittent foot shock stress on the hair cycle of C57BL/6 mice. After a 2-week period of intermittent foot shock stress, we examined the changes in the depilation-synchronized hair cycle macroscopically and histologically and we also measured the plasma levels of corticosterone. We found that foot shock stress prolonged the telogen stage and delayed the subsequent anagen induction in the hair cycle. The distribution patterns of corticotrophin releasing factor or corticotrophin releasing factor receptor positive cells in the skin of stressed or of control mice were identical with those in the ordinal hair cycle. It is noteworthy that corticotrophin releasing factor positive keratinocytes were observed in the telogen follicles of the stressed mice but were negative in the telogen follicles of the non-stressed mice in this study Plasma corticosterone levels were significantly higher in the stressed group than in the control group. These results suggest that increased levels of plasma corticosterone may be involved in the mechanism underlying the stress-induced delay of the hair cycle.