The calcium sensing receptor: from calcium sensing to signaling.
The calcium sensing receptor: from calcium sensing to signaling.
复制标题
钙传感受体：从钙传感到信号传导。
DOI：
10.1007/s11427-014-4779-y
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Yang,JennyJ
中科院分区：
文献类型：
--
作者：
Zhang,Chen;Miller,CassandraLynn;Brown,EdwardM;Yang,JennyJ
Ca2+敏感受体（CaSR）是一种G蛋白偶联受体，通过监测细胞外Ca2+（[Ca2+]o）水平并对各种刺激做出反应来调节体内Ca2+稳态。Ca2+敏感受体的突变可导致高钙血症或低钙血症，如家族性低钙尿性高钙血症、新生儿重度原发性甲状旁腺功能亢进和常染色体显性低钙性高钙尿症。令人信服的证据表明，CaSR发挥多种作用，不仅调节人体细胞外Ca2+的水平，而且还控制各种生物过程。在这篇综述中，我们专注于CaSR的结构生物学，配体相互作用位点以及它们与疾病相关突变的相关性。这一系统性的总结将提供一个全面的探索，如何将细胞外的Ca2+整合到细胞内的Ca2+信号。
The Ca2+-sensing receptor (the CaSR), a G-protein-coupled receptor, regulates Ca2+homeostasis in the body by monitoring extracellular levels of Ca2+([Ca2+]o) and responding to a diverse array of stimuli. Mutations in the Ca2+-sensing receptor result in hypercalcemic or hypocalcemic disorders, such as familial hypocalciuric hypercalcemia, neonatal severe primary hyperparathyroidism, and autosomal dominant hypocalcemic hypercalciuria. Compelling evidence suggests that the CaSR plays multiple roles extending well beyond not only regulating the level of extracellular Ca2+in the human body, but also controlling a diverse range of biological processes. In this review, we focus on the structural biology of the CaSR, the ligand interaction sites as well as their relevance to the disease associated mutations. This systematic summary will provide a comprehensive exploration of how the CaSR integrates extracellular Ca2+into intracellular Ca2+signaling.