Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome.
Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome.
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DOI：
10.1016/s0140-6736(04)16255-7
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发表时间：
2004-05-22
期刊：
影响因子：
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通讯作者：
Lim WW
中科院分区：
文献类型：
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作者：
Cheng PK;Wong DA;Tong LK;Ip SM;Lo AC;Lau CS;Yeung EY;Lim WW
严重急性呼吸道综合征（SARS）被认为是由一种新型冠状病毒（SARS相关冠状病毒）引起的。我们研究了SARS冠状病毒的病毒脱落，以提高诊断和感染控制。对2134份不同类型的标本进行了逆转录PCR检测。355例（45%）鼻咽抽吸物和150例（28%）粪便标本SARS冠状病毒RNA阳性。鼻咽抽吸物的阳性率在发病后6-11天达到峰值（87/149 [58%]，37/62 [60%]），粪便的阳性率在发病后9-14天达到峰值（15/22 [68%]，26/37 [70%]）。总的来说，病毒载量在患病的12-14天达到峰值，当时患者可能在医院接受治疗，这可以解释为什么医院工作人员容易感染。在发病的最初几天，病毒脱落率很低，这意味着早期隔离措施可能会有效。
Severe acute respiratory syndrome (SARS) is thought to be caused by a novel coronavirus, SARS-associated coronavirus. We studied viral shedding of SARS coronavirus to improve diagnosis and infection control. Reverse-transcriptase PCR was done on 2134 specimens of different types. 355 (45%) specimens of nasopharyngeal aspirates and 150 (28%) of faeces were positive for SARS coronavirus RNA. Positive rates peaked at 6–11 days after onset of illness for nasopharyngeal aspirates (87 of 149 [58%], to 37 of 62 [60%]), and 9–14 days for faeces (15 of 22 [68%], to 26 of 37 [70%]). Overall, peak viral loads were reached at 12–14 days of illness when patients were probably in hospital care, which would explain why hospital workers were prone to infection. Low rate of viral shedding in the first few days of illness meant that early isolation measures would probably be effective.