RESPECTIVE ROLES OF RADIOTHERAPY AND SURGERY IN THE MANAGEMENT OF EPIDERMOID CARCINOMA OF THE ANAL MARGIN - SERIES OF 57 PATIENTS
RESPECTIVE ROLES OF RADIOTHERAPY AND SURGERY IN THE MANAGEMENT OF EPIDERMOID CARCINOMA OF THE ANAL MARGIN - SERIES OF 57 PATIENTS
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DOI：
10.1007/bf02049397
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发表时间：
1992-05-01
影响因子：
3.9
通讯作者：
CHASSARD, JL
中科院分区：
文献类型：
--
作者：
PAPILLON, J;CHASSARD, JL
本文报道了54例放疗伴或不伴手术治疗的病例。粗略和特定癌症的5年生存率分别为59.2%和79.7%。3例患者接受姑息治疗。组织学类型、临床表现、疾病分期和患者状态的巨大差异证明了使用放疗、手术或两种方法结合的治疗策略的定义是合理的。T1和T2鳞状细胞癌或基底细胞癌适合局部切除后照射或单独照射。T3肿瘤和Bowen病应首先采用放射治疗。疣状癌适合局部手术后放射治疗。黏液表皮样癌和T4肿瘤适合术前放疗和延迟手术。最佳的放射技术包括在17天内通过钴-60给药并联合化疗（5-氟尿嘧啶和丝裂霉素C）给予40 Gy的剂量。除T1病变和基底细胞癌外，所有N0肿瘤均推荐对腹股沟区进行预防性照射。
The study of 54 patients treated curatively by irradiation with or without surgery is reported. The crude and cancer-specific five-year survival rates are 59.2 percent and 79.7 percent. Three patients were treated palliatively. The great variation in histologic type, clinical appearance, disease stage, and patient status justifies the definition of a treatment strategy using radiotherapy, surgery, or a combination of the two methods. T1 and T2 squamous- or basal-cell carcinomas are suitable for local excision followed by irradiation or for irradiation alone. T3 tumors and Bowen's disease should be treated by irradiation first. Verrucous carcinoma is suitable for local surgery followed by irradiation. Mucoepidermoid carcinoma and T4 tumors are suitable for preoperative irradiation and delayed surgery. The optimal radiation technique consists of delivering a dose of 40 Gy in 17 days by cobalt-60 with bolus and in combination with concomitant chemotherapy (5-fluorouracil and mitomycin C). Prophylactic irradiation of the inguinal area is recommended in all N0 tumors except for T1 lesions and basal-cell carcinomas.