Innate immunological function of TH2 cells in vivo.
Innate immunological function of TH2 cells in vivo.
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DOI：
10.1038/ni.3244
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发表时间：
2015-10
影响因子：
30.5
通讯作者：
Paul WE
中科院分区：
文献类型：
--
作者：
Guo L;Huang Y;Chen X;Hu-Li J;Urban JF Jr;Paul WE
2型辅助性T（TH）细胞在受到木瓜蛋白酶或屋尘螨（HDM）刺激时产生白细胞介素13（IL-13）并诱导嗜酸性粒细胞炎症。这种先天性应答依赖于IL-33而不是T细胞抗原受体（TCR）。虽然2型先天淋巴细胞（ILC 2）是幼稚动物中IL-13的主要先天生产者，但我们在这里表明，在蠕虫感染的小鼠中，TH 2细胞数量增加并成为先天II型反应的主要介质。TH 2细胞对HDM诱导的抗原非特异性嗜酸性粒细胞性炎症做出了重要贡献，并保护从猪蛔虫感染中恢复的小鼠免受随后的遗传学上远缘的线虫巴西日本圆线虫的感染。我们的研究结果揭示了以前不受重视的作用效应TH 2细胞在TCR非依赖性的先天性免疫反应。
Type 2 helper T (TH) cells produce interleukin 13 (IL-13) when stimulated by papain or house dust mites (HDM) and induce eosinophilic inflammation. This innate response is dependent on IL-33 but not T cell antigen receptors (TCRs). While type 2 innate lymphoid cells (ILC2s) are the dominant innate producers of IL-13 in naïve animals, we show here that in helminth-infected mice, TH2 cell numbers increased and became major mediators of innate type II responses. TH2 cells made important contributions to HDM-induced antigen–non-specific eosinophilic inflammation and protected mice recovering from Ascaris suum infection against subsequent infection with the phylogenetically distant nematode Nippostrongylus brasiliensis. Our findings reveal a previously unappreciated role of effector TH2 cells during TCR-independent innate-like immune responses.