Role of rodent models in advancing precision medicine for Parkinson's disease.
Role of rodent models in advancing precision medicine for Parkinson's disease.
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DOI：
10.1016/b978-0-323-85555-6.00002-3
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发表时间：
2023
影响因子：
--
通讯作者：
Fleming, Sheila M
中科院分区：
文献类型：
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作者：
Simons, Emily;Fleming, Sheila M
由于目前缺乏缓解疾病的治疗方法，一项旨在实施治疗帕金森病 (PD) 的精准医学方法的倡议已经出现。然而，如何定义和应用PD精准医学仍面临挑战。为了实现对每位患者进行最佳针对性和定时治疗的目标，在不同的啮齿动物模型群体中进行临床前研究将继续成为转化路径的重要组成部分，以确定用于患者诊断和分组的新型生物标志物，了解帕金森病的机制，确定新的治疗靶点，并在临床测试前筛选治疗方法。本综述重点介绍了最常见的 PD 啮齿动物模型，并讨论了这些模型如何有助于定义和实施 PD 治疗的精准医学。
With a current lack of disease-modifying treatments, an initiative toward implementing a precision medicine approach for treating Parkinson’s disease (PD) has emerged. However, challenges remain in how to define and apply precision medicine in PD. To accomplish the goal of optimally targeted and timed treatment for each patient, preclinical research in a diverse population of rodent models will continue to be an essential part of the translational path to identify novel biomarkers for patient diagnosis and subgrouping, understand PD disease mechanisms, identify new therapeutic targets, and screen therapeutics prior to clinical testing. This review highlights the most common rodent models of PD and discusses how these models can contribute to defining and implementing precision medicine for the treatment of PD.