Epidemiology of Meibomian Gland Dysfunction in an Elderly Population.
Epidemiology of Meibomian Gland Dysfunction in an Elderly Population.
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DOI：
10.1097/ico.0000000000000815
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发表时间：
2016-06
期刊：
影响因子：
2.8
通讯作者：
Galor A
中科院分区：
文献类型：
--
作者：
Alghamdi YA;Mercado C;McClellan AL;Batawi H;Karp CL;Galor A
研究老年男性人群中睑板腺功能障碍（MGD）的流行病学。对迈阿密退伍军人事务部眼科诊所的233名受试者进行的前瞻性研究。患者接受完整的眼表检查，包括干眼问卷和泪液评估（渗透压、泪液破裂时间（TBUT）、角膜染色、Schirmer）。主要的结果指标是睑板腺（MG）参数与人口统计学、干眼症状和泪液参数之间的相关性。研究的MG参数为眼睑血管分布和睑脂质量;任一参数评分≥2被视为异常。233名受试者的平均年龄为63岁（SD=11）; 91%为男性，59%至少有一项MG参数异常（质量异常55%;血管分布17%）。从人口统计学上看，MG参数异常的患者明显比无这些发现的患者年龄大。与黑人相比，白人更可能具有异常眼睑血管分布（n=36（31%）对n=1（1%），p < 0.0005），但在种族之间没有注意到关于睑脂质量的差异。异常的睑脂质量，而不是异常的血管，与更严重的干眼症状显著相关。类似地，异常的睑脂质量，而不是眼睑血管分布，与更差的干眼体征显著相关，包括降低的TBUT和增加的角膜染色（所有p<0.05）。MGD是老年人中常见的结果，主要是男性人群，在眼睑血管异常的频率方面存在种族差异，但在MG质量方面没有差异。异常的睑脂质量与更严重的干眼症状和体征显著相关。
To study the epidemiology of meibomian gland dysfunction (MGD) in an elderly, predominantly male population. Prospective study of 233 subjects seen in the Miami Veterans Affairs eye clinic. Patients underwent a complete ocular surface examination, including dry eye questionnaires and tear assessments (osmolarity, tear break up time (TBUT), corneal staining, Schirmer’s). The main outcome measures were correlations between meibomian gland (MG) parameters and demographics, dry eye symptoms, and tear parameters. The studied MG parameters were eyelid vascularity and meibum quality; a score of ≥2 in either parameter was considered abnormal. Mean age of the 233 subjects was 63 (SD=11); 91% were male and 59% had at least one abnormal MG parameter (abnormal quality 55%; vascularity 17%). Demographically, patients with abnormal MG parameters were significantly older than their counterparts without these findings. Whites were more likely to have abnormal eyelid vascularity compared to blacks (n=36 (31%) versus n=1 (1%), p < 0.0005) but no differences were noted between races with respect to meibum quality. Abnormal meibum quality, but not abnormal vascularity, was significantly associated with more severe dry eye symptoms. Similarly, abnormal meibum quality, but not eyelid vascularity, significantly associated with worse dry eye signs, including decreased TBUT, and increased corneal staining (p<0.05 for all). MGD is a frequent finding in an elderly, predominantly male population with racial differences noted in the frequency of abnormal eyelid vascularity but not in MG quality. Abnormal meibum quality was significantly associated with more severe dry eye symptoms and signs.