A functional form for a representative individual arterial input function measured from a population using high temporal resolution DCE MRI
A functional form for a representative individual arterial input function measured from a population using high temporal resolution DCE MRI
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DOI：
10.1002/mrm.27524
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发表时间：
2019-03-01
影响因子：
3.3
通讯作者：
Buckley, David L.
中科院分区：
文献类型：
--
作者：
Georgiou, Leonidas;Wilson, Daniel J.;Buckley, David L.
目的：使用优化的动态对比增强(DCE)成像序列在患者群体中测量动脉输入功能(AIF)，这是示踪剂动力学分析的重要组成部分，并估计患者间和患者内的变异性。从这些数据中，可以提取一个可用于真实模拟研究的具有代表性的AIF。方法：在乳腺癌新辅助化疗之前和过程中，对39名女性患者进行多次随访。总共分析了97项T-1加权DCE研究，包括对T-1的书末估计和对每个单独的AIF的模型拟合。曲线下面积和心输出量从每个首次通过峰值被估计，这些数据被用来评估AIF的患者间和患者内的变异性。结果：患者间的变异性超过了AIF的患者内变异性。心输出量并未因MR检查而改变(平均值为5.6+/-1.1 L/分钟)，但化疗开始后基础血T-1显著升高(伴随着红细胞压积的降低)。结论：单个患者的AIF是可以重复测量的，但患者之间的AIF的变异性表明，使用总体AIF将降低跨患者比较研究中进行示踪剂动力学分析的精确度。提出了一个具有代表性的AIF，它是人群的典型特征，但保留了单独测量的AIF的特征。
Purpose: To measure the arterial input function (AIF), an essential component of tracer kinetic analysis, in a population of patients using an optimized dynamic contrast-enhanced (DCE) imaging sequence and to estimate inter- and intrapatient variability. From these data, a representative AIF that may be used for realistic simulation studies can be extracted.Methods: Thirty-nine female patients were imaged on multiple visits before and during a course of neoadjuvant chemotherapy for breast cancer. A total of 97 T-1-weighted DCE studies were analyzed including bookend estimates of T-1 and model-fitting to each individual AIF. Area under the curve and cardiac output were estimated from each first pass peak, and these data were used to assess inter-and intrapatient variability of the AIF.Results: Interpatient variability exceeded intrapatient variability of the AIF. There was no change in cardiac output as a function of MR visit (mean value 5.6 +/- 1.1 L/min) but baseline blood T-1 increased significantly following the start of chemotherapy (which was accompanied by a decrease in hematocrit).Conclusion: The AIF in an individual patient can be measured reproducibly but the variability of AIFs between patients suggests that use of a population AIF will decrease the precision of tracer kinetic analysis performed in cross-patient comparison studies. A representative AIF is presented that is typical of the population but retains the characteristics of an individually measured AIF.