Paracingulate Sulcus Length Is Shorter in Voice-Hearers Regardless of Need for Care.
Paracingulate Sulcus Length Is Shorter in Voice-Hearers Regardless of Need for Care.
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无论是否需要护理，发声者的副扣带沟长度都较短。
DOI：
10.1093/schbul/sbaa067
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发表时间：
2020
影响因子：
6.6
通讯作者：
Corlett,PhilipR
中科院分区：
文献类型：
--
作者：
Powers,AlbertR;vanDyck,LauraI;Garrison,JaneR;Corlett,PhilipR
幻觉--虽然通常被认为是精神疾病的迹象--通常是那些不需要临床护理的人经历的。这些非临床听音者提供了一个在没有临床状态固有混淆的情况下调查幻觉的机会。最近的研究表明，在临床人群中，听觉言语幻觉(AVH)与内侧前额叶皮质旁齿状沟(PCS)的结构变异性之间存在关联。然而，在PCS长度被认为是临床幻觉风险的生物标志物之前，有必要研究具有AVH现象学的非临床听者群体的PCS结构。在目前的研究中，从四组参与者的T1加权结构MRI扫描中测量了PCS长度：(1)有精神障碍的听话者(n=15)；(2)没有精神障碍的听话者(n=15)；(3)有精神障碍的非听话者(n=14)；(4)没有精神障碍的非听话者(n=15)。AVH状态对右侧PCS长度有主要影响，而不是精神病性，AVH和精神病性之间没有交互作用。与无动静脉高压的参与者相比，患有动静脉曲张的参与者的右侧PCS长度变短(平均缩短8.8 mm，P<；0.05)。虽然过去的研究表明，临床听音者的PCS长度缩短，但我们的研究首次证明，较短的右侧PCS延伸到非临床听者。我们的发现支持这样一种假设，即PCS长度的差异与听到声音的倾向有关，而与疾病无关，这与声音-听力的连续统模型一致。
Hallucinations—while often considered an indication of mental illness—are commonly experienced by those without a need for clinical care. These nonclinical voice-hearers offer an opportunity to investigate hallucinations in the absence of confounds inherent to the clinical state. Recent work demonstrates an association between auditory verbal hallucinations (AVH) and structural variability in paracingulate sulcus (PCS) of medial prefrontal cortex in a clinical population. However, before PCS length may be considered a biomarker for clinical hallucination risk, it is necessary to investigate PCS structure in a nonclinical population of voice-hearers with AVH phenomenology similar to those of their clinical counterparts. In the current study, PCS length was measured from T1-weighted structural MRI scans of four groups of participants: (1) voice-hearers with a psychotic disorder (n = 15); (2) voice-hearers without a psychotic disorder (n = 15); (3) nonvoice-hearers with a psychotic disorder (n = 14); and (4) nonvoice-hearers without a psychotic disorder (n = 15). There was a main effect of AVH status—but not psychosis—on right PCS length, with no interaction of AVH and psychosis. Participants with AVH exhibited reduced right PCS length compared to participants without AVH (mean reduction = 8.8 mm, P < 0.05). While past studies have demonstrated decreased PCS length in clinical voice-hearers, ours is the first demonstration that shorter right PCS extends to nonclinical voice-hearers. Our findings support the hypothesis that differences in PCS length are related to the propensity to hear voices and not to illness, consistent with a continuum model of voice-hearing.