Second primary tumors in patients with upper aerodigestive tract cancers: joint effects of smoking and alcohol (United States)
Second primary tumors in patients with upper aerodigestive tract cancers: joint effects of smoking and alcohol (United States)
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DOI：
10.1023/a:1023060315781
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发表时间：
2003-03-01
影响因子：
2.3
通讯作者：
Spitz, MR
中科院分区：
文献类型：
--
作者：
Do, KA;Johnson, MM;Spitz, MR
目的：本研究评估了吸烟和饮酒对早期头颈部鳞状细胞癌（HNSCC）患者第二原发肿瘤（SPT）风险的联合影响。方法：1181例患者参加了安慰剂对照的13-顺式维甲酸化学预防试验。近17%的患者出现SPT。对数秩检验和考克斯比例风险模型被用来检查危险因素为SPT development.Results：调整后的时间从指数诊断到随机化，年龄在诊断，阶段和原发性癌症的部位，出现的因素，同时预测SPT的发展是继续吸烟和饮酒后，指数诊断。SPT风险增加与年龄较大有关（RR = 2.1; 95% CI 1.5-2.8）; II期诊断（RR = 1.5; 95% CI 1.1-2.1）;咽癌的索引诊断（RR = 1.6; 95% CI 1.1-2.5）;登记时当前吸烟结论：HNSCC治疗后持续吸烟、饮酒与SPT的发生有重要关系。
Objective: This study evaluated the joint effects of tobacco smoking and alcohol consumption on the risk of second primary tumors (SPT) in patients with early-stage head and neck squamous cell carcinoma (HNSCC).Methods: Data are presented for 1181 patients enrolled in a placebo-controlled chemoprevention trial of 13-cis-retinoic acid. Nearly 17% of patients presented with a SPT. The log rank test and Cox proportional hazards model were used to examine risk factors for SPT development.Results: After adjusting for the time from the index diagnosis to randomization, age at diagnosis, stage, and site of the primary cancer, the factors that emerged as simultaneous predictors of SPT development were continued smoking and alcohol intake after the index diagnosis. Increased SPT risk was associated with older age (RR = 2.1; 95% CI 1.5-2.8); stage II diagnosis (RR = 1.5; 95% CI 1.1-2.1); index diagnosis of pharyngeal cancer (RR = 1.6; 95% CI 1.1-2.5); current smoking at registration (RR = 2.1; 95% CI 1.3-3.6) and continued alcohol consumption post-diagnosis (RR = 1.3; 95% CI 1.0-1.7).Conclusion: Important associations exist between SPT development and continued smoking and alcohol consumption after treatment for HNSCC.