Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome
Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome
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DOI：
10.1053/j.gastro.2012.06.031
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发表时间：
2012-10-01
期刊：
影响因子：
29.4
通讯作者：
Nieuwdorp, Max
中科院分区：
文献类型：
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作者：
Vrieze, Anne;Van Nood, Els;Nieuwdorp, Max
肠道微生物群的改变与肥胖和胰岛素抵抗有关。我们研究了将来自瘦供体的肠道微生物群输注给患有代谢综合征的男性受体对受体微生物群组成和葡萄糖代谢的影响。受试者被随机分配到给予小肠输注同种异体或自体微生物群的组。输注来自瘦供体的微生物群6周后，受体的胰岛素敏感性增加（葡萄糖消失的中位速率从26.2 μ mol/kg/min变为45.3 μ mol/kg/min; P <0.05）沿着产生丁酸盐的肠道微生物群水平也增加。肠道微生物群可能被开发为治疗剂，以增加人类的胰岛素敏感性; www.trialregister.nl;在荷兰试验登记处注册（NTR 1776）。
Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male recipients with metabolic syndrome on the recipients' microbiota composition and glucose metabolism. Subjects were assigned randomly to groups that were given small intestinal infusions of allogenic or autologous microbiota. Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased (median rate of glucose disappearance changed from 26.2 to 45.3 mu mol/kg/min; P < .05) along with levels of butyrate-producing intestinal microbiota. Intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans; www.trialregister.nl; registered at the Dutch Trial Register (NTR1776).