Near-infrared spectroscopic study of frontopolar activation during face-to-face conversation in major depressive disorder and bipolar disorder.
Near-infrared spectroscopic study of frontopolar activation during face-to-face conversation in major depressive disorder and bipolar disorder.
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DOI：
10.1016/j.jpsychires.2014.06.009
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发表时间：
2014-10
影响因子：
4.8
通讯作者：
Y. Takei;M. Suda;Y. Aoyama;N. Sakurai;Minami Tagawa;T. Motegi;Miho Yamaguchi;K. Narita;M. Fukuda
中科院分区：
文献类型：
--
作者：
Y. Takei;M. Suda;Y. Aoyama;N. Sakurai;Minami Tagawa;T. Motegi;Miho Yamaguchi;K. Narita;M. Fukuda
重度抑郁障碍（MDD）和双相情感障碍（BD）患者的言语特征随着情绪状态的变化而变化很大。在之前的研究中，我们发现精神分裂症患者在面对面交谈时颞叶和右侧额下回（IFG）激活受损；然而，之前没有研究调查过面对面交谈时的情绪障碍。在这里，我们研究了重度抑郁症和双相障碍患者交谈时额叶和颞叶的激活情况。使用近红外光谱（NIRS）测量了29名重度抑郁症患者、31名双相障碍患者和31名正常对照（NC）的额叶和颞叶激活情况。我们比较了连续激活和快速激活与谈话/听阶段变化的关系，并分析了这些指标与临床变量的相关性。MDD和BD组均表现出左背外侧前额叶（DLPFC）和左额极皮质（FPCs）持续激活减少；他们还显示双侧FPC激活的快速变化减少。在重度抑郁症组中，激活的快速变化与整体功能评估（GAF）得分呈正相关。在BD组，持续激活与发病年龄呈负相关。上述结果表明，交谈时的额叶激活在MDD和BD中均有所减少，但持续激活和快速变化可能反映了MDD和BD的病理生理特征；特别是，右侧FPC快速变化量的减少可能与MDD患者的适应能力受损有关。
Major depressive disorder (MDD) and bipolar disorder (BD) patients show speech characteristics that vary greatly according to mood state. In a previous study, we found impaired temporal and right inferior frontal gyrus (IFG) activation in schizophrenia during face-to-face conversation; no study had, however, previously investigated mood disorders during face-to-face conversation. Here, we investigated frontal and temporal lobe activation during conversation in patients with MDD and BD. Frontal and temporal lobe activation was measured using near-infrared spectroscopy (NIRS) in 29 patients with MDD, 31 patients with BD, and 31 normal controls (NC). We compared continuous activation and rapid change of activation with talk/listen phase changes during the conversation and analyzed the correlation between these indices and clinical variables. Both the MDD and BD groups showed decreased continuous activation in the left dorsolateral prefrontal (DLPFC) and left frontopolar cortices (FPCs); they also showed decreased rapid change in bilateral FPC activation. In the MDD group, the rapid change of activation was positively correlated with Global Assessment of Functioning (GAF) scores. In the BD group, continuous activation was negatively correlated with age of onset. These results indicate that frontal activation during conversation decreases in both MDD and BD. However, both continuous activation and rapid change may reflect the pathophysiological character of MDD and BD; in particular, the reduced amount of rapid change in the right FPC may be related to impaired adaptive ability in MDD.