Frailty and Its Correlates in Adults With Late Life Depression
Frailty and Its Correlates in Adults With Late Life Depression
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DOI：
10.1016/j.jagp.2019.10.005
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发表时间：
2020-02-01
影响因子：
7.2
通讯作者：
Rutherford, Bret R.
中科院分区：
文献类型：
--
作者：
Brown, Patrick J.;Roose, Steven P.;Rutherford, Bret R.
目的：调查老年抑郁症（LLD）患者的虚弱率和虚弱特征，并检查虚弱的临床和神经心理学相关性。研究方法：数据来自对134名年龄超过60岁（45名男性，89名女性）的抑郁症诊断者的评估，他们参加了抑郁症治疗研究。通过磁共振成像评估抑郁、神经心理功能、白色高信号（WMH）负荷和虚弱特征。结果如下：25%的样本存在油炸虚弱负担（>= 3个特征），当使用临床上有意义的步态速度截分时，这一比例增加到45.5%（
Objective: To investigate the rates of frailty and frailty characteristics and examine the clinical and neuropsychological correlates of frailty in adults with late life depression (LLD). Methods: Data were used from the evaluation of 134 individuals over the age of 60 years (45 men, 89 women) with a depressive diagnosis who enrolled in studies for the treatment of their depression. Depression, neuropsychological functioning, white matter hyperintensity (WMH) burden via magnetic resonance imaging, and characteristics of frailty were assessed. Results: Fried frailty burden (>= 3 characteristics) was present in 25% of the sample, with this rate increasing to 45.5% when using clinically meaningful cut-scores for gait speed (