Goblet cell autoantibodies in patients with inflammatory bowel disease and their first-degree relatives
Goblet cell autoantibodies in patients with inflammatory bowel disease and their first-degree relatives
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DOI：
10.1016/s0016-5085(97)70085-4
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发表时间：
1997-07-01
期刊：
影响因子：
29.4
通讯作者：
Fricke, H
中科院分区：
文献类型：
--
作者：
Folwaczny, C;Noehl, N;Fricke, H
背景与目的：克罗恩病和溃疡性结肠炎具有家族聚集性。在这两种疾病中，抗杯状细胞自身抗体（GABs）已被描述。本研究的目的是确定GABA在炎症性肠病发病机制中的作用。研究方法：研究人群包括61例溃疡性结肠炎患者，76例克罗恩病患者，101例溃疡性结肠炎患者的一级亲属和105例克罗恩病患者的一级亲属。35例感染性小肠结肠炎患者和56例健康无关受试者作为对照组。间接免疫荧光法检测自身抗体。结果如下：39%的溃疡性结肠炎患者（61例中的24例）和30%的克罗恩病患者（76例中的23例）为GABA阳性。在溃疡性结肠炎患者的一级亲属中检测到21%（21/101）的GABA，在克罗恩病患者的一级亲属中检测到19%（20/105）的GABA。在感染性小肠结肠炎患者和健康对照中，分别在3%（1/35）和2%（1/56）中观察到GABA。对照组与两组患者或其一级亲属之间的差异均有统计学意义。结论：在一级亲属中的高患病率表明，GABs可能是炎症性肠病易感性的标志物。
Background & Aims: Crohn's disease and ulcerative colitis show a familial aggregation. In both diseases, anti-goblet cell autoantibodies (GABs) have been described. The aim of this study was to define the role of GABs in the pathogenesis of inflammatory bowel disease. Methods: The study population comprised 61 patients with ulcerative colitis, 76 patients with Crohn's disease, 101 first-degree relatives of patients with ulcerative colitis, and 105 first-degree relatives of patients with Crohn's disease. Thirty-five patients with infectious enterocolitis and 56 healthy unrelated subjects sewed as controls. Autoantibodies were detected by indirect immunofluorescence. Results: Thirty-nine percent of patients with ulcerative colitis (24 of 61) and 30% of patients with Crohn's disease (23 of 76) were positive for GABs. GABs were detected in 21% (21 of 101) of first-degree relatives of patients with ulcerative colitis and in 19% (20 of 105) of first-degree relatives of patients with Crohn's disease, In patients with infectious enterocolitis and in healthy controls, GABs were seen in 3% (1 of 35) and 2% (1 of 56), respectively. The differences between control groups and both groups of patients or their first-degree relatives were significant. Conclusions: The high prevalence in first-degree relatives suggests that GABs may represent a marker characterizing susceptibility to inflammatory bowel disease.