SERUM PROLACTIN RESPONSE TO THYROTROPIN-RELEASING-HORMONE AND METOCLOPRAMIDE IN PATIENTS WITH PROLACTIN-SECRETING TUMORS BEFORE AND AFTER TRANSSPHENOIDAL SURGERY
SERUM PROLACTIN RESPONSE TO THYROTROPIN-RELEASING-HORMONE AND METOCLOPRAMIDE IN PATIENTS WITH PROLACTIN-SECRETING TUMORS BEFORE AND AFTER TRANSSPHENOIDAL SURGERY
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DOI：
10.1210/jcem-47-5-1148
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发表时间：
1978-01-01
影响因子：
5.8
通讯作者：
ANILE, C
中科院分区：
文献类型：
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作者：
BARBARINO, A;DEMARINIS, L;ANILE, C
本文对7例女性闭经、溢乳和高泌乳素血症患者在选择性经蝶窦切除泌乳素微腺瘤前后进行了检查。腺瘤切除术前，甲氧氯普胺（MCP；口服10 mg）和促甲状腺激素释放激素（TRH） （200 .mu）。（静脉注射）没有增加任何7例患者的PRL血水平。口服10 mg MCP后，8名哺乳期妇女产后3天出现阳性反应。术后血清PRL水平均恢复正常。术后1个月，7例患者中有6例PRL对MCP和TRH有阳性反应。一名PRL水平最低的患者在两种刺激后均未出现PRL升高。经蝶窦切除垂体prl分泌瘤后，下丘脑垂体功能明显恢复正常。
Seven female patients with amenorrhea, galactorrhea and hyperprolactinemia were examined before and after selective transsphenoidal removal of a PRL[prolactin]-secreting microadenoma. Before adenomectomy, metoclopramide (MCP; 10 mg orally) and TRH [thyrotropin-releasing hormone] (200 .mu.g i.v.) did not increase PRL blood levels in any of the 7 patients. After oral administration of 10 mg MCP a positive response was noted in a group of 8 lactating women 3 days postpartum. After surgery, serum PRL level returned to normal in all patients. A positive PRL response to MCP and TRH was found in 6 of the 7 patients 1 mo. after surgery. One patient who had the lowest PRL level failed to show a PRL increase after both stimuli. Hypothalamic pituitary function apparently can be restored to normal after transsphenoidal removal of PRL-secreting pituitary tumors.