CYTOLOGICAL STUDIES OF FIBER TYPES IN SKELETAL MUSCLE
CYTOLOGICAL STUDIES OF FIBER TYPES IN SKELETAL MUSCLE
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骨骼肌纤维类型的细胞学研究
DOI：
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发表时间：
1966
影响因子：
7.8
通讯作者：
H. A. Padykula
中科院分区：
文献类型：
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作者：
G. F. Gauthier;H. A. Padykula
对哺乳动物膈肌的比较研究揭示了红肌和白色肌纤维的某些细胞学方面与功能活动之间的相关性。这种骨骼肌在哺乳动物中具有相似和恒定的功能，但其功能活性以定量的方式变化。呼吸率（以及横膈膜收缩率）和代谢活动都与身体大小呈负相关;这项研究证明了横膈膜细胞学特征与动物身体大小之间的关系。富含线粒体的小纤维（红色纤维）是小型哺乳动物的特征，它们具有高代谢活性和快呼吸速率;而线粒体含量相对较低的大纤维在大型哺乳动物中占主导地位，它们具有较低的代谢活性和较慢的呼吸速率。在身体大小介于这两组之间的哺乳动物（包括实验室大鼠）中，横膈膜由不同类型的纤维组成。一般来说，膈肌纤维的线粒体含量与身体大小呈负相关。因此，红色纤维似乎反映了高度的代谢活动，或者在该肌肉所表现出的范围内相对较高的收缩率。
A comparative investigation of the mammalian diaphragm has revealed a correlation between certain cytological aspects of red and white muscle fibers and functional activity. This skeletal muscle presents the advantage of a similar and constant function among the mammals, but its functional activity varies in a quantitative manner. Both the rate of breathing (and hence the rate of contraction of the diaphragm) and metabolic activity are known to be inversely related to body size; and this study has demonstrated a relationship between cytological characteristics of the diaphragm and body size of the animal. Small fibers rich in mitochondria (red fibers) are characteristic of small mammals, which have high metabolic activity and fast breathing rates; and large fibers with relatively low mitochondrial content predominate in large mammals, which have lower metabolic activity and slower breathing rates. In mammals with body size intermediate between these two groups (including the laboratory rat), the diaphragm consists of varying mixtures of fiber types. In general, the mitochondrial content of diaphragm fibers is inversely related to body size. It appears, then, that the red fiber reflects a high degree of metabolic activity or a relatively high rate of contraction within the range exhibited by this muscle.