Use of optical imaging to progress novel therapeutics to the clinic
Use of optical imaging to progress novel therapeutics to the clinic
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DOI：
10.1016/j.jconrel.2013.05.004
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发表时间：
2013-12-10
影响因子：
10.8
通讯作者：
Tangney, Mark
中科院分区：
文献类型：
--
作者：
Byrne, William L.;DeLille, Alexandra;Tangney, Mark
毫无争议地需要使用和改进强大的技术来实时分析基因和细胞疗法临床转化中的治疗传递和反应。在过去的十年中，光学成像因其效率、实用性和经济性而成为许多临床前实验室选择的体内成像方式，而最近，该技术的临床潜力正变得越来越明显。这篇综述提供了体内光学成像技术的最新进展，并讨论了这种快速改进的技术，因为它本身代表了一种翻译推动者或实际上是一种未来的临床成像模式。 (C) 2013 Elsevier B.V. 保留所有权利。
There is an undisputed need for employment and improvement of robust technology for real-time analyses of therapeutic delivery and responses in clinical translation of gene and cell therapies. Over the past decade, optical imaging has become the in vivo imaging modality of choice for many preclinical laboratories due to its efficiency, practicality and affordability, while more recently, the clinical potential for this technology is becoming apparent. This review provides an update on the current state of the art in in vivo optical imaging and discusses this rapidly improving technology in the context of it representing a translation enabler or indeed a future clinical imaging modality in its own right. (C) 2013 Elsevier B.V. All rights reserved.