Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton
Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton
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DOI：
10.1016/s0092-8674(01)00222-7
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发表时间：
2001-02-09
期刊：
影响因子：
64.5
通讯作者：
Tabin, CJ
中科院分区：
文献类型：
--
作者：
Hartmann, C;Tabin, CJ
脊椎动物无骨骨骼的长骨起源于最初连续的间充质细胞凝聚，随后分裂和空化形成由滑膜关节分离的离散元件，然而，关于关节形成的分子机制知之甚少。我们目前的证据表明，Wnt-14在启动鸡肢滑膜关节形成中起着核心作用。Wnt-14在软骨成分分割之前在关节形成区域中表达，并且Wnt-14的局部错误表达诱导关节形成的第一步骤的特征性形态和分子变化。通过Wnt-14诱导异位关节样区域抑制了紧邻内源性关节的形成，可能提供对关节间距的了解。
The long bones of the vertebrate appendicular skeleton arise from initially continuous condensations of mesenchymal cells that subsequently segment and cavitate to form discrete elements separated by synovial joints, tittle is known, however, about the molecular mechanisms of joint formation. We present evidence that Wnt-14 plays a central role in initiating synovial joint formation in the chick limb. Wnt-14 is expressed in joint-forming regions prior to the segmentation of the cartilage elements, and local misexpression of Wnt-14 induces morphological and molecular changes characteristic of the first steps of joint formation. Induction of an ectopic joint-like region by Wnt-14 suppresses the formation of the immediately adjacent endogenous joint, potentially providing insight into the spacing of joints.