Role of interleukin-15 in the development of mouse olfactory nerve
Role of interleukin-15 in the development of mouse olfactory nerve
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DOI：
10.1111/j.1741-4520.2009.00246.x
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发表时间：
2009-12-01
影响因子：
1.3
通讯作者：
Otani, Hiroki
中科院分区：
文献类型：
--
作者：
Umehara, Tsuyoshi;Udagawa, Jun;Otani, Hiroki
白介素15与白介素2受体(R)的成分相互作用，表现出与白介素2类似的T细胞刺激活性。此外，IL-15在许多细胞类型和组织中广泛表达，包括中枢神经系统。我们提供了IL-15在嗅神经发生中的新作用的证据。IL-15和IL-15Rα在发育中的小鼠嗅觉上皮神经前体细胞中均有表达。与野生型相比，成年IL-15Rα基因敲除小鼠的成熟嗅觉神经元和增殖细胞较少。结果提示，IL-15在嗅神经发生过程中对细胞增殖起着重要的调控作用。
Interleukin (IL)-15 interacts with components of the IL-2 receptor (R) and exhibits T cell-stimulating activity similar to that of IL-2. In addition, IL-15 is widely expressed in many cell types and tissues, including the central nervous system. We provide evidence of a novel role of IL-15 in olfactory neurogenesis. Both IL-15 and IL-15R alpha were expressed in neuronal precursor cells of the developing olfactory epithelium in mice. Adult IL-15R alpha knockout mice had fewer mature olfactory neurons and proliferating cells than wild-type. Our results suggest that IL-15 plays an important role in regulating cell proliferation in olfactory neurogenesis.