Expression of DJ-1 in Cancer Cells: Its Correlation with Clinical Significance
Expression of DJ-1 in Cancer Cells: Its Correlation with Clinical Significance
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DOI：
10.1007/978-981-10-6583-5_4
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Iwaya, Keiichi
中科院分区：
文献类型：
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作者：
Kawate, Takahiko;Tsuchiya, Benio;Iwaya, Keiichi
乳腺癌、非小细胞肺癌、胰腺癌、尿路移行细胞癌、妇科肿瘤等多种人类肿瘤中DJ-1mRNA表达上调。在蛋白质水平上，DJ-1的表达强度和细胞内定位是不同的，DJ-1蛋白调节肿瘤的进展、临床侵袭性、分化、癌细胞形态和药物敏感性。因此，DJ-1在癌症中起着关键作用。虽然DJ-1在癌细胞内具有重要作用，但癌细胞在细胞外分泌DJ-1。DJ-1可以作为一种肿瘤标志物，从血液、分泌液、腹水或胸腔积液的早期阶段就可以检测到。
Upregulation of DJ-1 mRNA is commonly observed in various human cancers such as ductal carcinoma of the breast, non-small cell carcinoma of the lung, pancreatic duct adenocarcinoma, urinary transitional cell carcinoma, and gynecologic carcinoma. At the protein level, intensity and intracellular localization of DJ-1 expression is varied, and the DJ-1 protein regulates cancer progression, clinical aggressiveness, differentiation, cancer cell morphology, and drug sensitivity. Thus, DJ-1 plays a critical role in cancer. Although DJ-1 has an important role within cancer cells, cancer cells secrete DJ-1 outside the cells. DJ-1 may serve as a tumor marker that can be detected from an early stage in the blood, secretory fluids, ascites, or pleural effusion.