Early social enrichment augments adult hippocampal BDNF levels and survival of BRDU-positive cells while increasing anxiety- and "depression"-like behavior
Early social enrichment augments adult hippocampal BDNF levels and survival of BRDU-positive cells while increasing anxiety- and "depression"-like behavior
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DOI：
10.1002/jnr.20789
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发表时间：
2006-05-01
影响因子：
4.2
通讯作者：
Alleva, E
中科院分区：
文献类型：
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作者：
Branchi, I;D'Andrea, I;Alleva, E
早期经历会影响成年后的大脑功能和行为。在一个共同的巢(CN)中饲养，由三个母亲将它们的幼崽放在一起，从出生到断奶(出生后25天)分担照顾行为，为发育中的幼崽提供了一个高度的社会刺激环境。公共巢是包括老鼠在内的许多啮齿动物物种的自然生态位的特征。成年后，与在标准筑巢实验室条件(SN)饲养的小鼠相比，CN饲养的小鼠海马区BDNF蛋白水平增加，BrdU阳性细胞存活时间更长。开阔场地和高架+迷宫的结果表明，尽管CN小鼠表现出与SN小鼠相似的探索和运动活动水平，但表现出更多的焦虑样行为，在开阔的场地表现出更多的运动能力，在+迷宫的张开手臂上花费的时间更少。此外，CN小鼠在强迫游泳测试中表现出更高水平的不动行为。总体而言，这些发现表明，CN，一个高度刺激的早期社会环境，增加了成年神经元的可塑性，正如高BDNF水平和海马体中新生成的细胞数量增加所表明的那样，这与焦虑和抑郁样行为的增加有关。这些发现在抑郁症的神经营养素假说的框架内进行了讨论。(C)2006年Wiley-Liss，Inc.
Early experiences affect brain function and behavior at adulthood. Being reared in a communal nest (CN), consisting of a single nest where three mothers keep their pups together and share care-giving behavior from birth to weaning (postnatal day [PND] 25), provides an highly socially stimulating environment to the developing pup. Communal nest characterizes the natural ecologic niche of many rodent species including the mouse. At adulthood, CN reared mice, compared to mice reared in standard nesting laboratory condition (SN), show an increase in BDNF protein levels and longer survival of BrdU-positive cells in the hippocampus. Open field and elevated plus maze results indicate that CN mice, although showing levels of exploratory and locomotor activity similar to those of SN mice, displayed increased anxiety-like behavior, performing more thigmotaxis in the open field and spending less time in the open arms of the plus maze. Furthermore, CN mice displayed higher levels of immobility behavior in the forced swim test. Overall, these findings show that CN, an highly stimulating early social environment, increases adult neuronal plasticity, as suggested by high BDNF levels and augmented number of newly generated cells in the hippocampus, which is associated to an increased anxiety- and "depression"-like behavior. These findings are discussed in the framework of the neurotrophin hypothesis of depression. (c) 2006 Wiley-Liss, Inc.