An animal model for the tickborne flavivirus Omsk hemorrhagic fever virus
An animal model for the tickborne flavivirus Omsk hemorrhagic fever virus
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DOI：
10.1086/426397
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发表时间：
2005-01-01
影响因子：
6.4
通讯作者：
Barrett, ADT
中科院分区：
文献类型：
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作者：
Holbrook, MR;Aronson, JF;Barrett, ADT
黄病毒的蜱传脑炎（TBE）血清复合体主要由引起神经系统疾病的病毒组成;这些病毒包括鄂木斯克出血热病毒（OHFV），该病毒在遗传上与其他TBE血清复合体病毒相关，但在生态学上不同的生态位中循环并引起明显不同的人类疾病。本研究的目的是检查一个潜在的小动物模型OHFV和比较感染的病理嗜神经蜱传黄病毒，Powassan病毒（POWV）。感染POWV的BALB/c小鼠表现出典型的虫媒病毒性脑炎，其特征在于死亡前的轻瘫和瘫痪，以及大脑的病毒感染，其特征在于炎症和坏死。相反，致死性OHFV感染并不引起大脑麻痹或显著感染，但显示小脑明显受累。脾脏不同的病理结果表明，OHFV感染的小鼠的免疫应答与POWV感染的小鼠不同。本研究证明了OHFV感染的小鼠和POWV感染的小鼠之间存在明显的病理学差异，并支持使用BALB/c小鼠作为OHFV的疾病模型。
The tickborne encephalitis (TBE) serocomplex of flaviviruses consists primarily of viruses that cause neurologic disease; these viruses include Omsk hemorrhagic fever virus (OHFV), a virus that is genetically related to other TBE serocomplex viruses but that circulates in an ecologically distinct niche and causes markedly different human disease. The objective of this study was to examine a potential small-animal model for OHFV and to compare the pathology of infection with that of the neurotropic tickborne flavivirus, Powassan virus (POWV). POWV-infected BALB/c mice demonstrated typical arboviral encephalitis, characterized by paresis and paralysis before death, and viral infection of the cerebrum, characterized by inflammation and necrosis. In contrast, lethal OHFV infection did not cause paralysis or significant infection of the cerebrum but showed marked involvement of the cerebellum. Distinct pathological results in the spleens suggest that the immune response in OHFV-infected mice is different from that in POWV-infected mice. This study demonstrates a clear pathological difference between OHFV-infected mice and POWV-infected mice and supports the use of the BALB/c mouse as a disease model for OHFV.