Effects of daily adherence to antihypertensive medication on blood pressure control.
Effects of daily adherence to antihypertensive medication on blood pressure control.
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DOI：
10.1111/j.1751-7176.2011.00427.x
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Kressin NR
中科院分区：
文献类型：
--
作者：
Rose AJ;Glickman ME;D'Amore MM;Orner MB;Berlowitz D;Kressin NR
当患者报告他/她最近错过了几次降压药物剂量时，临床医生通常不确定如何管理血压升高（BP）。虽然我们知道更好的坚持可以在几个月内改善BP，但这种关系在短期内的程度却知之甚少。我们使用一组使用药物事件监测系统（MEMS帽）监测依从性并在常规临床实践过程中进行BP测量的患者来研究这个问题。我们比较了良好依从性（100%）或不良依从性（<60%）7天后的血压读数，忽略了中等依从性后的血压值。使用几种不同的方法，我们发现7天的良好依从性后的血压比7天的不良依从性后的血压低12/7和15/8 mm/Hg。临床医生可以使用这个效应量来校准他们对BP可能已经改善的依从性的印象。
Clinicians are often uncertain how to manage an elevated blood pressure (BP) when a patient reports that he/she has recently missed several doses of the antihypertensive medications. While we know that better adherence can improve BP over several months, the magnitude of this relationship in the short term is poorly understood. We examined this issue using a group of patients who monitored adherence using the Medication Events Monitoring System (MEMS caps) and had BP measurements in the course of routine clinical practice. We compared BP readings following seven days of excellent adherence (100%) or poor adherence (<60%), omitting BP values following intermediate adherence. Using several different methods, we found that BP following seven days of excellent adherence is between 12/7 and 15/8 mm/Hg lower than after seven days of poor adherence. Clinicians can use this effect size to calibrate their impressions of what the BP might have been with improved adherence.
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