Integrin cytoplasmic domains as connectors to the cell's signal transduction apparatus.
Integrin cytoplasmic domains as connectors to the cell's signal transduction apparatus.
复制标题
整合素细胞质结构域作为细胞信号转导装置的连接器。
DOI：
10.1016/s0945-053x(97)90003-2
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Mastrangelo,AM
中科院分区：
文献类型：
--
作者：
LaFlamme,SE;Homan,SM;Bodeau,AL;Mastrangelo,AM
整合素介导信号在质膜上的双向传递。整合素细胞质结构域提供了连接整合素参与细胞信号转导装置的一条途径。最近的结构-功能研究已经确定了整合素功能所需的β细胞质结构域区域，并确定了单个α细胞质结构域在调节细胞行为中的不同作用。新发现的结合整合素α和β细胞质结构域的蛋白质为整合素信号传导的机制提供了新的见解和新的问题。
Integrins mediate the bidirectional transfer of signals across the plasma membrane. Integrin cytoplasmic domains provide one pathway linking integrin engagement with the cell's signal transduction apparatus. Recent structure-function studies have defined regions of β cytoplasmic domains required for integrin function and have identified distinct roles for individual α cytoplasmic domains in regulating cell behavior. Newly identified proteins that bind to integrin α and β cytoplasmic domains have provided new insights and new questions into the mechanisms involved in integrin signaling.