Salvage surgery for oropharyngeal squamous cell carcinomas: A retrospective study from 2005 to 2013
Salvage surgery for oropharyngeal squamous cell carcinomas: A retrospective study from 2005 to 2013
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DOI：
10.1002/hed.24827
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发表时间：
2017-09-01
影响因子：
2.9
通讯作者：
Ceruse, Philippe
中科院分区：
文献类型：
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作者：
Philouze, Pierre;Peron, Julien;Ceruse, Philippe
背景：在口咽鳞状细胞癌局部复发的病例中，治疗标准是手术治疗。我们这项研究的主要目的是确定术前预后因素，使我们能够选择我们期望通过挽救性手术获得良好结果的患者。方法：2005 - 2013年进行单中心回顾性研究。它包括所有因口咽鳞状细胞癌复发而接受手术治疗的患者。他们最初的治疗包括放射治疗。结果：纳入52例患者。预后不良的生存因素是cT状态（P = 0.0039）、局部复发与放射区继发定位（P = 0.016）以及初始治疗结束后不到一年的复发（P = 0.050）。5年无复发生存率为19%。29%的患者出现局部并发症，主要是手术部位的瘘管和出血。结论：针对该病的高致死率，应慎重选择合适的手术患者。
Background: In the case of a locoregional recurrence of oropharyngeal squamous cell carcinoma, the curative standard of care is surgery. Our main purpose of this study was to determine the preoperative prognostic factors that would allow us to select the patients on whom we could expect good results with salvage surgery.Methods: We conducted a monocentric retrospective study from 2005 to 2013. It included all patients treated for a recurrence of oropharyngeal squamous cell carcinoma with surgery. Their initial treatment included radiotherapy.Results: Fifty-two patients were included. Poor prognostic factors for survival were the cT status (P = .0039) and local recurrences versus secondary localizations in irradiated areas (P = .016) and a relapse less than a year after the end of the initial treatment (P = .050). Recurrence-free survival was 19% at 5 years. Twenty-nine percent of patients presented local complications, which were mainly fistulas and hemorrhaging at the surgical site.Conclusion: According to the high morbimortality, it is important to carefully select the right patients for surgery.