Effects of Jitai Tablet, A Traditional Chinese Medicine, on Spontaneous Withdrawal Symptoms and Modulation of Dopaminergic Functions in Morphine‐Dependent Rats
Effects of Jitai Tablet, A Traditional Chinese Medicine, on Spontaneous Withdrawal Symptoms and Modulation of Dopaminergic Functions in Morphine‐Dependent Rats
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DOI：
10.1002/ptr.5300
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发表时间：
2015-05
影响因子：
7.2
通讯作者：
Shaoang Tu;Jinlong Gao;Jia Liu;Jin-ming Zhang;Yiyun Huang;Shasha Xu;Mei Han;Jianhui Liang
中科院分区：
文献类型：
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作者：
Shaoang Tu;Jinlong Gao;Jia Liu;Jin-ming Zhang;Yiyun Huang;Shasha Xu;Mei Han;Jianhui Liang
慢性阿片类药物滥用可导致多巴胺神经元损伤。然而，目前没有有效的药物疗法来扭转这种损害，尽管在开发阿片类药物依赖的治疗策略方面取得了进展。济泰片（JTT）是中国最常用于阿片类药物成瘾治疗的传统中药制剂。在吗啡自发戒断大鼠模型中，我们研究了在吗啡给药之前（治疗前）或之后（治疗后）给予JTT对多巴胺系统的影响。我们的研究表明：（1）JTT预处理和后处理可有效缓解湿狗样抖动和扭体发作;（2）JTT预处理可抑制吗啡诱导的纹状体多巴胺转运蛋白（DAT）、多巴胺D2受体（D2 R）和酪氨酸羟化酶（TH）水平降低（3）JTT后处理使纹状体中DAT、D2 R和TH的密度恢复至正常水平（p < 0.01，与吗啡组相比）。这些结果支持了这样的观点，即纹状体中多巴胺系统的调节可能对JTT缓解阿片类戒断症状的治疗效果起作用。版权所有© 2015约翰威利父子有限公司
Chronic opioid abuse can cause damage to dopamine neurons. However, there are currently no effective pharmacotherapies to reverse this damage, even though progress has been made in the development of therapeutic strategies for opioid dependence. The Jitai tablet (JTT) is a traditional Chinese medicine formulation most commonly used for opioid addiction treatment in China. In a morphine spontaneous withdrawal rat model we investigated the effects of JTT, either given before (pre‐treatment) or after (post‐treatment) morphine administration, on the dopamine system. Our study has shown the following: (1) pre‐ and post‐treatment with JTT were effective at alleviating the wet dog shakes and episodes of writhing; (2) pre‐treatment with JTT inhibited the morphine‐induced decreases in dopamine transporter (DAT), dopamine D2 receptor (D2R) and tyrosine hydroxylase (TH) levels in the striatum (p < 0.01, compared with morphine group) and maintained them at normal levels; and (3) post‐treatment with JTT restored the densities of DAT, D2R and TH in the striatum to normal levels (p < 0.01, compared with morphine group). These results support the notion that modulation of the dopamine system in the striatum may play a role for JTT's therapeutic effect on the alleviation of opioid withdrawal symptoms. Copyright © 2015 John Wiley & Sons, Ltd.