Influenza burden of illness - Estimates from a national prospective survey of household contacts in France
Influenza burden of illness - Estimates from a national prospective survey of household contacts in France
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DOI：
10.1001/archinte.162.16.1842
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发表时间：
2002-09-09
影响因子：
--
通讯作者：
Rouzioux, C
中科院分区：
文献类型：
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作者：
Carrat, F;Sahler, C;Rouzioux, C
背景：门诊患者中流感的负担仍然相对未知，尽管这一知识对于评估应对流感的策略至关重要。方法：2000年1月4日至3月15日，在法国进行了一项全国性的前瞻性家庭接触研究，收集了946户看医生的家庭(指示病例)；395户流感阳性的家庭完成了随访，评估了流感对这些指示病例及其接触者的临床影响、就诊、治疗和损失工作日。结果：在817名可评估的家庭接触者中，313人发生了临床流感(继发病例)；178人(57%)至少看过一次医生(咨询二次病例)。确诊病例的中位病程为8d(95%可信区间，7~8d)，咨询继发病例为7d(95%可信区间，7~8d)，非咨询继发病例为4d(95%可信区间，3~5d)(P
Background: The burden of influenza among ambulatory patients is still relatively unknown, although this knowledge is crucial for evaluating strategies against influenza. We estimated the impact of influenza in terms of uncomplicated morbidity and its consequences on health care utilization and lost workdays.Methods: A national prospective household contact study between January 4, 2000, and March 15, 2000, in France recruited the households of 946 persons who visited a physician (index cases); 395 households with influenza-positive index cases completed the follow-up, which assessed the clinical impact of influenza, medical visits, treatment, and lost workdays in these index cases and their contacts.Results: Of 817 assessable household contacts, 313 developed clinical influenza (secondary cases); 178 (57%) of them visited a physician at least once (consulting secondary cases). The median duration of illness was 8 days (95% confidence interval [CI], 7-8 days) in index cases, 7 days (95% CI, 7-8 days) in consulting secondary cases, and 4 days (95% CI, 3-5 days) in nonconsulting secondary cases (P