PRODUCTION OF IMMUNOREACTIVE INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND IGF-I BINDING-PROTEINS BY HUMAN LUNG-TUMORS
PRODUCTION OF IMMUNOREACTIVE INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND IGF-I BINDING-PROTEINS BY HUMAN LUNG-TUMORS
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DOI：
10.1038/bjc.1990.163
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发表时间：
1990-05-01
影响因子：
8.8
通讯作者：
BLEEHEN, NM
中科院分区：
文献类型：
--
作者：
REEVE, JG;PAYNE, JA;BLEEHEN, NM
研究了体外人肺肿瘤细胞系产生胰岛素样生长因子I（IGF-I）和IGF-I结合蛋白（BP）的情况，并研究了肺癌患者血清中这些物质的水平。小细胞肺癌（SCLC）细胞系分泌IGF-I和BP，而非小细胞肺癌（NSCLC）细胞系仅分泌BP。在52例具有SCLC和NSCLC组织学的肺癌患者的队列中未获得血清IGF-I水平升高的证据。与此相反，血清中的低分子量的BPs水平显着升高，在大多数肺癌患者。
The production of insulin-like growth factor I (IGF-I) and IGF-I binding proteins (BPs) by human lung tumour cell lines in vitro has been examined and the levels of these substances in the serum of lung cancer patients investigated. While small cell lung cancer (SCLC) cell lines secreted both IGF-I and BPs, non-small cell lung cancer (NSCLC) cell lines secreted BPs only. No evidence of increased serum IGF-I levels was obtained in a cohort of 52 lung cancer patients having SCLC and NSCLC histologies. In contrast, serum levels of low molecular weight BPs were markedly elevated in the majority of lung cancer patients.