Complications and postoperative events after cryosurgery for prostate cancer
Complications and postoperative events after cryosurgery for prostate cancer
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DOI：
10.1111/j.1464-410x.2011.10423.x
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发表时间：
2012-03-01
影响因子：
4.5
通讯作者：
Polascik, Thomas J.
中科院分区：
文献类型：
--
作者：
Caso, Jorge R.;Tsivian, Matvey;Polascik, Thomas J.
在泌尿学文献中一直呼吁对并发症进行标准化报告。使用严格的标准，旨在报告我们的并发症和其他术后事件，在一组接受第三代前列腺冷冻手术的男性中。患者和方法收集了2002 - 2010年接受初次冷冻手术的男性的形态学、临床和病理学数据，排除接受新辅助或辅助放疗的患者。并发症和事件被广泛定义为预期术后病程的任何偏离和随访期间表达的任何主观主诉。使用卡方检验和秩和检验进行描述性统计，并进行Logistic回归分析以评估任何并发症的潜在预测因素总共有106名连续的患者被确定为艾德，没有术中并发症或设备故障。我们观察到42例早期并发症，其中48例为延迟性事件，10例为晚期事件。共有5例（4.7%）患者出现持续性急迫性和/或压力性尿失禁。31例患者术前和术后均有国际前列腺症状评分（IPSS）和烦恼指数评分; IPSS和烦恼指数的中位评分分别从7分和2分降至6分和1分。24例患者术前和2年随访时的男性性健康量表评分;中位评分从11下降到2.On多变量分析，there are no significi cant associations.CONCLUSIONSModern cryosurgery是安全的，大多数并发症和术后事件是短暂的。然而，勃起功能明显恶化。我们无法确定并发症或术后事件的显著风险因素。
OBJECTIVESThere has been a call in the urological literature for standardized reporting of complications.To use strict criteria aiming to report our complications and other postoperative events in a cohort of men undergoing third-generation prostate cryosurgery.PATIENTS AND METHODSDemographic, clinical and pathological data were collected on men undergoing primary cryosurgery from 2002 - 2010, excluding those who had received neoadjuvant or adjuvant radiotherapy.Complications and events were broadly defi ned as any deviation from the expected postoperative course and any subjective complaint expressed during a follow- up visit.Descriptive statistics were generated and compared between groups using chisquared and rank sum tests as appropriate.Logistic regression analyses were performed to assess the potential predictors of any complication or event.RESULTSIn total, 106 consecutive patients were identifi ed.There were no intra-operative complications or instances of equipment failure. We observed 42 early complications, with 48 delayed and 10 late postoperative events.A total of fi ve ( 4.7%) patients had persistent urge and/ or stress incontinence.Thirty-one patients had International Prostate Symptom Score (IPSS) and bother index scores available before and after surgery; median scores decreased from 7 and 2 to 6 and 1, for IPSS and bother index, respectively. Twenty-four patients had Sexual Health Inventory for Men scores available before surgery and at 2-year follow-up; median scores decreased from 11 to 2.On multivariate analysis, there were no signifi cant associations.CONCLUSIONSModern cryosurgery is safe, and most of the complications and postoperative events are transient. Erectile function, however, has marked deterioration. We were unable to identify signifi cant risk factors for complications or postoperative events.