Risk of laryngeal and nasopharyngeal cancer associated with arsenic and cadmium in the Tunisian population
Risk of laryngeal and nasopharyngeal cancer associated with arsenic and cadmium in the Tunisian population
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DOI：
10.1007/s11356-013-2105-z
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发表时间：
2014-02-01
影响因子：
5.8
通讯作者：
Hamza-Chaffai, Amel
中科院分区：
文献类型：
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作者：
Khlifi, Rim;Olmedo, Pablo;Hamza-Chaffai, Amel
长期以来，人们一直认为，长期接触重金属会增加接触人群中头颈部癌症(HNC)的发病率，如喉癌(LC)和鼻咽癌(NPC)。本研究的目的是测定145例LC和NPC患者及351例正常对照血中砷(As)和镉(Cd)的浓度，以确定这些因素与LC和NPC发生的潜在关系。血砷和镉的平均水平(分别为5.67和3.51 mU/L)显著高于对照组(分别为1.57和0.74 mU/L)。控制吸烟、咀嚼、饮酒等HNC危险因素后，血As、Cd水平明显高于对照组(P<；0.05)。血镉水平随着患者职业接触年限的增加而显著升高(p<；0.05)。然而，没有发现海鲜是一种接触来源。在这些危险因素中，吸烟(>；30包年)和职业暴露(>；20年)与HNC的相关性最显著(OR分别为10.22和10.38，p<；0.001)。职业性接触者/吸烟者(吸烟者和咀嚼者)的血镉水平高于非职业性接触者/非吸烟者(P<；0.001)。Logistic回归模型显示，HNC(LC+NPC)与血AS(OR=2.41p<；0.001)和Cd(OR=4.95p<；0.001)水平显著相关。
Chronic exposure to heavy metals has long been recognized as being capable of increasing head and neck cancer (HNC) incidence, such as laryngeal (LC) and nasopharyngeal (NPC), among exposed human populations. The aim of the present study was to evaluate the concentrations of arsenic (As) and cadmium (Cd) in the blood of 145 patients (LC and NPC) and 351 controls in order to establish a potential relationship between these factors and the occurrence of LC and NPC. Mean blood levels of As and Cd in patients (5.67 and 3.51 mu g/L, respectively) were significantly higher than those of controls (1.57 and 0.74 mu g/L, respectively). The blood levels of As and Cd were mostly significantly higher than those of controls (p < 0.05) after controlling the other risk factors of HNC including tobacco smoking and chewing, and alcohol drinking. Cd levels in blood increase significantly with the number of occupational exposure years for patients (p < 0.05). However, seafood was not found to be contributing as an exposure source. Among these risk factors, smoking (>30 pack years) and occupational exposure (>20 years) presented the most significant association with HNC (OR = 10.22 and 10.38, respectively, p < 0.001). Cd level in blood sample of cases that are occupationally exposed/tobacco users (smokers and chewers) were higher than that of non-occupationally exposed/nontobacco users (p < 0.001). The logistic regression model illustrated that HNC (LC + NPC) was significantly associated with blood levels of As (OR = 2.41, p < 0.001) and Cd (OR = 4.95, p < 0.001).